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Dr. Samuel Sheppard
Genome-wide association studies in bacteria

enero 10, 2019 @ 4:00 pm - 4:45 pm

Evento Navegación

Bacteria display extraordinary variation in phenotypes such as virulence, tissue specificity and host range, and understanding the genetic basis of this diversity is a pervasive aim in microbiology. Advances in whole genome sequencing are providing new opportunities for improved understanding of bacterial epidemiology and evolution. However, while many laboratories are now sequencing 1000s of bacterial genomes, developing methods for analyzing this data remains a significant challenge.Promising approaches, pioneered in human genetics, include genome-wide association studies (GWAS) where DNA sequence variation across the genome is related to particular phenotypes. This has been challenging to apply to bacteria because of their open pan genomes and strong population structure resulting from clonal reproduction. Recent work, including Sheppard et al (PNAS, 2013), presents new methods that identify homologous and non-homologous sequence variation in Campylobacter. This revealed some of the genetic changes associated with the adaptation of this important human pathogen from its ancestral host (birds) to mammals. This methodology has since been applied to diverse organisms including Staphylococcus and Helicobacter. In this talk I will describe recent studies in which GWAS have improved understanding of the genetic basis of phenotypic variation and have led to novel insights into bacterial evolution, including the identification of virulence, transmission and survival factors in pathogens as well as broader insights into the ecological genomics in non-pathogenic strains.

Seminario CCG.
Auditorio “Dr. Guillermo Soberón” Centro de Ciencias Genómicas.
Dr. Samuel Sheppard


enero 10, 2019
4:00 pm - 4:45 pm
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Auditorio Dr. Guillermo Soberón CCG
Centro de Ciencias Genómicas UNAM
Cuernavaca, Morelos Mexico


Centro de Ciencias Genómicas UNAM