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Dr. Nicholas Priest
Non-adaptive evolution in microbes

enero 10, 2019 @ 4:45 pm - 5:30 pm

Evento Navegación

Seminario CCG.
Auditorio “Dr. Guillermo Soberón” Centro de Ciencias Genómicas.
Dr. Nicholas Priest

Natural systems are remarkably resilient to environmental change. We know that microbes can rapidly evolve to new conditions by altering how they regulate gene expression. But, we do not know whether regulatory re-wiring is driven by Darwinian adaptation or non-adaptive forces, such as mutation and random genetic drift. This talk shows that non-adaptive evolution may have a central role in the evolution of microbial pathogenicity. Using computational biology, we find that compensatory mutation can stimulate increased regulatory complexity in the absence of natural selection.  Research we have conducted in the bacterium, Pseudomonas fluorescens, indicates that compensatory evolution in a nitrogen assimilation pathway governing motility is surprisingly repeatable. And, recent evidence in the litterature implicates non-adaptive origins of pathogenicity. Darwin’s theory may not apply.


enero 10, 2019
4:45 pm - 5:30 pm
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Auditorio Dr. Guillermo Soberón CCG
Centro de Ciencias Genómicas UNAM
Cuernavaca, Morelos Mexico


Centro de Ciencias Genómicas UNAM