Mario Alberto Serrano Ortega

Functional Genomics of Eukaryotes Researcher

Associate Professor

Academic history

Mario Serrano studied agronomic engineer at the “Antonio Narro” Agrarian Autonomous University, Mexico. He did his Master and Doctoral studies at the Center for Research and Advanced Studies of the National Polytechnic Institute, Campus Irapuato (CINVESTAV-Irapuato) under the supervision of Plinio Guzmán. From 2004 to 2008 he received a postdoctoral fellow from the Max-Planck Society, to work at the Max-Planck Institute for Plant Breeding Research, Cologne, Germany, in the Group of Paul Schulze-Lefert. Afterwards, from 2008 until 2014, he held a Junior group leader position at the University of Fribourg, Switzerland in the Group of Jean-Pierre Métraux. From 2015 he holds the position of Associate Professor at the Center for Genome Sciences at the National Autonomous University of Mexico (UNAM) Campus Morelos, Mexico.

The focus of his work is the characterization of the plant innate immunity to the necrotroph fungus Botrytis cinerea, commonly known as grey mold, that has been classified as the second most important plant pathogen. The early events that take place during B. cinerea infection, in particular the communication between the plant and the pathogen at the cuticle are not completely elucidated. Our project is based on the identification and characterization of the molecular elements that link the degradation of the cuticle and the induction of the plant innate immunity. To achieve this objective, we use the plant-pathogen system Arabidopsis thalianaBotrytis cinerea and the traditional genomic and chemical genetic methods. Additionally, we are interested in identifying and molecularly characterizing biostimulants from the microbiome of animals and plants, which can limit the damage caused by this phytopathogen.

He is Associate Editor of Frontiers in Plant Science and Review Editor of Frontiers in Microbiology.


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Telephone: (777) 3115164


2022Brazales-Cevallos, D.K., Romero-Contreras, Y.J., Vences-Guzmán, M.Á., Torres, M., Aviles-Baltazar, N.Y., Sohlenkamp, C., Serrano, M.. (2022). "Transcriptional characterization of the biostimulant effect of Moringa oleifera leaf extracts using Arabidopsis thaliana as a model.". S AFR J BOT. 144():250-256. [doi:10.1016/j.sajb.2021.09.011]
2022Castro-Bustos S, Maruri-López I, Ortega-Amaro MA, Serrano M, Ovando-Vázquez C, Jiménez-Bremont JF. (2022). "An interactome analysis reveals that Arabidopsis thaliana GRDP2 interacts with proteins involved in post-transcriptional processes.". CELL STRESS CHAPERON. ():-. [doi:10.1007/s12192-022-01261-5]35174430
2021García-Soto I, Boussageon R, Cruz-Farfán YM, Castro-Chilpa JD, Hernández-Cerezo LX, Bustos-Zagal V, Leija-Salas A, Hernández G, Torres M, Formey D, Courty PE, Wipf D, Serrano M, Tromas A. (2021). "The Lotus japonicus ROP3 Is Involved in the Establishment of the Nitrogen-Fixing Symbiosis but Not of the Arbuscular Mycorrhizal Symbiosis.". Frontiers In Plant Science. 12():696450-696450. [doi:10.3389/fpls.2021.696450]34868100
2021Aragón, W., Formey, D., Aviles-Baltazar, N.Y., Torres, M., Serrano, M.. (2021). "Arabidopsis thaliana Cuticle Composition Contributes to Differential Defense Response to Botrytis cinerea". Frontiers In Plant Science. 12():-. [doi:10.3389/fpls.2021.738949]34804086
2021Herrera-González, J.A., Bautista-Baños, S., Serrano, M., Romanazzi, G., Gutiérrez-Martínez, P.. (2021). "Non-Chemical Treatments for the Pre- and Post-Harvest Elicitation of Defense Mechanisms in the Fungi-Avocado Pathosystem". Molecules. 26(22):-. [doi:10.3390/molecules26226819]34833910
2021Ziazia P, Poulaki E, Gkizi D, Lozano L, Serrano M, Tjamos S. (2021). "Feeding the Microbes: A Strategy to Control Verticillium Wilt". Agronomy. 11(10):1946-. [doi:]
2021Batista-Oliveira, J.S., Formey, D., Torres, M., Aragón, W., Romero-Contreras, Y.J., Maruri-López, I., Tromas, A., Schwan-Estrada, K.R.F., Serrano, M.. (2021). "Gadolinium Protects Arabidopsis thaliana against Botrytis cinerea through the Activation of JA/ET-Induced Defense Responses.". INT J MOL SCI. 22(9):-. [doi:10.3390/ijms22094938]34066536
2021Córdoba-Castro, L.A., Salgado-Morales, R., Torres, M., Martínez-Aguilar, L., Lozano, L., Vences-Guzmán, M.Á., Guan, Z., Dantán-González, E., Serrano, M., Sohlenkamp, C.. (2021). "Ornithine Lipids in Burkholderia spp. Pathogenicity.". Frontiers in molecular biosciences. 7():-. [doi:10.3389/fmolb.2020.610932]33469548
2021Coronado-Partida, L.D., Serrano, M., González-Estrada, R.R., Gutiérrez-Martínez, P.. (2021). "Application of GRAS compounds to control soft rot in jackfruit (Artocarpus heterophyllus L.) caused by Rhizopus stolonifer". TIP Revista Especializada en Ciencias Químico-Biológicas. 24():1-7. [doi:10.22201/fesz.23958723e.2021.327]
2020Narváez-Barragán DA, Tovar-Herrera OE, Torres, Martha, Rodríguez M, Humphris S, Toth IK, Segovia L, Serrano M, Martínez-Anaya C. (2020). "Expansin-like Exl1 from Pectobacterium is a virulence factor required for host infection, and induces a defence plant response involving ROS, and jasmonate, ethylene and salicylic acid signalling pathways in Arabidopsis thaliana.". SCIENTIFIC REPORTS. 10(1):7747-7747. [doi:10.1038/s41598-020-64529-9]32385404
2020Veeragoni, S.R., Lange, B., Serrano, M., Nawrath, C., Bauer, S., Schäffner, A.R., Thordal-Christensen, H., Durner, J., Gaupels, F.. (2020). "Mutant Muddle: Some Arabidopsis eds5 Mutant Lines Have a Previously Unnoticed Second-Site Mutation in FAH1 .". Plant Physiology. 182(1):460-462. [doi:10.1104/pp.19.01125]31685644
2020Chávez-Martínez AI, Ortega-Amaro MA, Torres M, Serrano M, Jiménez-Bremont JF. (2020). "Arabidopsis adc-silenced line exhibits differential defense responses to Botrytis cinerea and pseudomonas syringae infection.". PLANT PHYSIOLOGY AND BIOCHEMISTRY. 156():494-503. [doi:10.1016/j.plaphy.2020.09.035]33049445
2020Dorcas Zúñiga-Silgado, Julio C Rivera-Leyva, Jeffrey J Coleman, Ayixon Sánchez-Reyez, Susana Valencia-Díaz, Mario Serrano, Luz E de-Bashan, Jorge L Folch-Mallol. (2020). "Soil Type Affects Organic Acid Production and Phosphorus Solubilization Efficiency Mediated by Several Native Fungal Strains from Mexico". Microorganisms. 8(9):-. [doi:10.3390/microorganisms8091337]32887277
2020Narváez-Barragán DA, Tovar-Herrera OE, Segovia L, Serrano M, Martinez-Anaya C. (2020). "Expansin-related proteins: biology, microbe-plant interactions and associated plant-defense responses.". MICROBIOLOGY-SGM. 166(11):1007-1018. [doi:10.1099/mic.0.000984]33141007
2019Maruri-Lopez, Israel, Yaniri Aviles-Baltazar, Norma, Buchala, Antony, Serrano, Mario. (2019). "Intra and Extracellular Journey of the Phytohormone Salicylic Acid.". Frontiers In Plant Science. 10():-. [doi:10.3389/fpls.2019.00423]31057566
2018Ferreira-Saab, M., Formey, D., Torres, M., Aragón, W., Padilla, E.A., Tromas, A., Sohlenkamp, C., Schwan-Estrada, K.R.F., Serrano, M.. (2018). "Compounds released by the biocontrol yeast Hanseniaspora opuntiae protect plants against Corynespora cassiicola and Botrytis cinerea". Frontiers in Microbiology. 9(JUL):1596-1596. [doi:10.3389/fmicb.2018.01596]30065716
2018Blanc, Catherine, Coluccia, Fania, L'Haridon, Floriane, Torres, Martha, Ortiz-Berrocal, Marlene, Stahl, Elia, Reymond, Philippe, Schreiber, Lukas, Nawrath, Christiane, Metraux, Jean-Pierre, Serrano, Mario. (2018). "The cuticle mutant eca2 modifies plant defense responses to biotrophic and necrotrophic pathogens and herbivory insects". Molecular Plant-Microbe Interactions. 31(3):344-355. [doi:10.1094/MPMI-07-17-0181-R]29130376
2017Aragon, Wendy, Juan Reina-Pinto, Jose, Serrano, Mario. (2017). "The intimate talk between plants and microorganisms at the leaf surface". Journal Of Experimental Botany. 68(19):5339-5350. [doi:10.1093/jxb/erx327]29136456
2016Gkizi, Danai, Lehmann, Silke, L'Haridon, Floriane, Serrano, Mario, Paplomatas, Epaminondas J., Metraux, Jean-Pierre, Tjamos, Sotirios E.. (2016). "The innate immune signaling system as a regulator of disease resistance and induced systemic resistance activity against Verticillium dahliae". Molecular Plant-Microbe Interactions. 29(4):313-323. [doi:10.1094/MPMI-11-15-0261-R]26780421
2015Hael-Conrad, V., Abou-Mansour, E., Diaz-Ricci, J. -C., Metraux, J. -P., Serrano, M.. (2015). "The novel elicitor AsES triggers a defense response against Botrytis cinerea in Arabidopsis thaliana". Plant Science. 241():120-127. [doi:10.1016/j.plantsci.2015.09.025]26706064

Publications from former affiliations

Año Publicación PMID
2015 Abou-Mansour, E, Debieux, J, Ramirez-Suero, M, Benard-Gellon, M, Magnin-Robert, M, Spagnolo, A, Chong, J, Farine, S, Bertsch, C, L’Haridon, F, Serrano, M, Fontaine, F, Rego, C, Larignon, P. (2015). “Phytotoxic metabolites from Neofusicoccum parvum, a pathogen of Botryosphaeria dieback of grapevine”. Phytochemistry. 115(1):207-215. [doi:10.1016/j.phytochem.2015.01.012] 25747381
2015 Serrano, M, Kombrink, E, Meesters, C. (2015). “Considerations for designing chemical screening strategies in plant biology”. Frontiers In Plant Science. 6(APR):131-131. [doi:10.3389/fpls.2015.00131] 25904921
2015 Lehmann, S, Serrano, M, L’Haridon, F, Tjamos, S, Metraux, J. (2015). “Reactive oxygen species and plant resistance to fungal pathogens”. Phytochemistry. 112(1):54-62. [doi:10.1016/j.phytochem.2014.08.027] 25264341
2014 Serrano, M, Coluccia, F, Torres, M, L’Haridon, F, Metraux, J. (2014). “The cuticle and plant defense to pathogens”. Frontiers In Plant Science. 5(JUN):274-274. [doi:10.3389/fpls.2014.00274] 24982666
2013 Silva, Y, Portieles, R, Pujol, M, Terauchi, R, Matsumura, H, Serrano, M, Borras-Hidalgo, O. (2013). “Expression of a microbial serine proteinase inhibitor gene enhances the tobacco defense against oomycete pathogens”. PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY. 84(1):99-106. [doi:10.1016/j.pmpp.2013.08.001]
2013 Benikhlef, L, L’Haridon, F, Abou-Mansour, E, Serrano, M, Binda, M, Costa, A, Lehmann, S, Metraux, J. (2013). “Perception of soft mechanical stress in Arabidopsis leaves activates disease resistance”. Bmc Plant Biology. 13(1):133-133. [doi:10.1186/1471-2229-13-133] 24033927
2013 Serrano, M, Wang, B, Aryal, B, Garcion, C, Abou-Mansour, E, Heck, S, Geisler, M, Mauch, F, Nawrath, C, Metraux, J. (2013). “Export of salicylic acid from the chloroplast requires the multidrug and toxin extrusion-like transporter EDS5″. Plant Physiology. 162(4):1815-1821. [doi:10.1104/pp.113.218156] 23757404
2012 Serrano, M, Kanehara, K, Torres, M, Yamada, K, Tintor, N, Kombrink, E, Schulze-Lefert, P, Saijo, Y. (2012). “Repression of sucrose/ultraviolet B light-induced flavonoid accumulation in microbe-associated molecular pattern-triggered immunity in Arabidopsis“. Plant Physiology. 158(1):408-422. [doi:10.1104/pp.111.183459] 22080602
2011 L’Haridon, F, Besson-Bard, A, Binda, M, Serrano, M, Abou-Mansour, E, Balet, F, Schoonbeek, H, Hess, S, Mir, R, Leon, J, Lamotte, O, Metraux, J. (2011). “A permeable cuticle is associated with the release of reactive oxygen species and induction of innate immunity”. PLOS PATHOGENS. 7(7):e1002148-. [doi:10.1371/journal.ppat.1002148] 21829351
2011 Fragniere, C, Serrano, M, Abou-Mansour, E, Metraux, J, L’Haridon, F. (2011). “Salicylic acid and its location in response to biotic and abiotic stress”. FEBS LETTERS. 585(12):1847-1852. [doi:10.1016/j.febslet.2011.04.039] 21530511
2010 Serrano, M, Hubert, D, Dangl, J, Schulze-Lefert, P, Kombrink, E. (2010). “A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thaliana“. Planta. 231(5):1013-1023. [doi:10.1007/s00425-010-1105-1] 20140739
2007 Serrano, M, Robatzek, S, Torres, M, Kombrink, E, Somssich, I, Robinson, M, Schulze-Lefert, P. (2007). “Chemical interference of pathogen-associated molecular pattern-triggered immune responses in Arabidopsis reveals a potential role for fatty-acid synthase type II complex-derived lipid signals”. JOURNAL OF BIOLOGICAL CHEMISTRY. 282(9):6803-6811. [doi:10.1074/jbc.M608792200] 17166839
2006 Serrano, M, Parra, S, Alcaraz, L, Guzman, P. (2006). “The ATL gene family from Arabidopsis thaliana and Oryza sativa comprises a large number of putative ubiquitin ligases of the RING-H2 type”. Journal Of Molecular Evolution. 62(4):434-445. [doi:10.1007/s00239-005-0038-y] 16557337
2004 Serrano, M, Guzman, P. (2004). “Isolation and gene expression analysis of Arabidopsis thaliana mutants with constitutive expression of ATL2, an early elicitor-response RING-H2 zinc-finger gene”. Genetics. 167(2):919-929. [doi:10.1534/genetics.104.028043] 15238540