David Salvador Zamorano Sánchez

Genomic Microbiology Researcher

Assistant Professor

Academic history

David Zamorano-Sánchez has a BSc in Basic Biomedical Research and a PhD in Biomedical Sciences from Universidad Nacional Autónoma de México (UNAM). He specialized in the fields of bacterial genetics and functional genomics of prokaryotes, developing diverse projects that dealt with transcriptional regulation of genes involved in the nitrosative stress response, biofilm formation and nitrogen fixation. In 2013 he started a postdoctoral position at the University of California, Santa Cruz, where he led projects that focused on the study of signal perception and signal transduction in Vibrio cholerae. Since February 2018 he joined the Center for Genomic Sciences at UNAM as an Assistant Professor. His laboratory studies the molecular basis for decision making in bacteria at a systemic level.

The research lines of his group have the main purpose of understanding how diverse signal transduction systems (e.g. two component systems, alternative sigma factors and second messengers) control social behavior and stress response of pathogenic vibrios. The main genetic tools employed in his lab are forward genetics, reverse genetics, functional genomics, chemical genetics and synthetic biology.

He is a Review Editor for the journal Frontiers in Microbiology.


Google Scholar

Selected publications

1. Conner JG, Zamorano-Sánchez D, Park JH, Sondermann H, Yildiz FH. 2017. The ins and outs of cyclic di-GMP signaling in Vibrio cholerae. Curr Opin Microbiol 36:20-29.
2. Teschler JK, Zamorano-Sánchez D, Utada AS, Warner CJA, Wong GCL, Linington RG, Yildiz FH. 2015. Living in the matrix: assembly and control of Vibrio cholerae biofilms. Nat Rev Microbiol 13:255-68.
3. Wang Y-C, Chin K-H, Tu Z-L, He J, Jones CJ, Sanchez DZ, Yildiz FH, Galperin MY, Chou S-H. 2016. Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain. Nat Commun 7:12481.
4. Zamorano-Sánchez D, Fong JCN, Kilic S, Erill I, Yildiz FH. 2015. Identification and characterization of VpsR and VpsT binding sites in Vibrio cholerae. J Bacteriol 197:1221-35.
5. Warner CJA, Salinas M, Zamorano-Sánchez D, Bray WM, Lokey RS, Yildiz FH, Linington RG. 2018. The bioactive lipid ( S )-sebastenoic acid impacts motility and dispersion in Vibrio cholerae. Can J Chem 96:196-203.

Telephone: (777) 3291777 Ext. 38487
Email: zamorano@ccg.unam.mx


2021Sierra Cacho, D., Zamorano Sánchez, D.S., Xiqui-Vázquez, M.L., Viruega Góngora, V.I., Ramírez-Mata, A., Baca, B.E.. (2021). "CdgC, a Cyclic-di-GMP Diguanylate Cyclase of Azospirillum baldaniorum Is Involved in Internalization to Wheat Roots.". Frontiers In Plant Science. 12():-. [doi:10.3389/fpls.2021.748393]34745182
2021Martínez-Méndez, R., Camacho-Hernández, D.A., Sulvarán-Guel, E., Zamorano-Sánchez, D.. (2021). "A Trigger Phosphodiesterase Modulates the Global c-di-GMP Pool, Motility, and Biofilm Formation in Vibrio parahaemolyticus.". Journal Of Bacteriology. 203(13):-. [doi:10.1128/JB.00046-21]33846117
2020Rodriguez, Susana, Correa-Galeote, David, Sanchez-Perez, Mishael, Ramirez, Mario, Isidra-Arellano, Mariel C., Reyero-Saavedra, Maria del Rocio, Zamorano-Sanchez, David, Hernandez, Georgina, Valdes-Lopez, Oswaldo, Girard, Lourdes. (2020). "A Novel OmpR-Type Response Regulator Controls Multiple Stages of the Rhizobium etliPhaseolus vulgaris N2-Fixing Symbiosis". Frontiers in Microbiology. 11():-. [doi:10.3389/fmicb.2020.615775]33384681
2020Martínez-Ortiz, I.C., Ahumada-Manuel, C.L., Hsueh, B.Y., Guzmán, J., Moreno, S., Cocotl-Yañez, M., Waters, C.M., Zamorano-Sánchez, D., Espín, G., Núñeza, C.. (2020). "Cyclic di-GMP-Mediated Regulation of Extracellular Mannuronan C-5 Epimerases Is Essential for Cyst Formation in Azotobacter Vinelandii.". Journal Of Bacteriology. 202(24):-. [doi:10.1128/JB.00135-20]32989089
2020Ahumada-Manuel, C.L., Martínez-Ortiz, I.C., Hsueh, B.Y., Guzmán, J., Waters, C.M., Zamorano-Sánchez, D., Espín, G., Núñez, C.. (2020). "Increased c-di-GMP Levels Lead to the Production of Alginates of High Molecular Mass in Azotobacter Vinelandii.". Journal Of Bacteriology. 202(24):-. [doi:10.1128/JB.00134-20]32989088
2020Wu, D.C., Zamorano-Sánchez, D., Pagliai, F.A., Park, J.H., Floyd, K.A., Lee, C.K., Kitts, G., Rose, C.B., Bilotta, E.M., Wong, G.C.L., Yildiz, F.H.. (2020). "Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation.". Plos Genetics. 16(3):-. [doi:10.1371/journal.pgen.1008703]32176702
2015Girard Cuesy, María de Lourdes, Zamorano Sánchez, David Salvador. (2015). "Fnr - like proteins in Rhizobia: past and future". Biological Nitrogen Fixation. 1():155-166. [doi:10.1002/9781119053095]
2015Zamorano-Sanchez, David, Girard, Lourdes. (2015). "Fnr-Like Proteins in Rhizobia: Past and Future". Biological Nitrogen Fixation, Vols 1 And 2. ():155-165.
2013Ramírez Yáñez, Mario, Guillén, G., Fuentes Membreño, Sara Isabel, Iñiguez Rabago, Luis Pedro, Aparicio Fabre, Rosaura, Zamorano Sánchez, David Salvador, Encarnación Guevara, Sergio Manuel, Panzeri, D., Castiglioni, B., Cremonesi, P., Strozzi, F., Stella, A., Girard Cuesy, María de Lourdes, Sparvoli, F., Hernández Delgado, Georgina. (2013). "Transcript profiling of common bean nodules subjected to oxidative stress". Physiologia Plantarum. 149(3):389-407. [doi:10.1111/ppl.12040]23432573
2013Reyes González, Alma Ruth, Zamorano Sánchez, David Salvador, Rivera Rosas, Patricia, Girard Cuesy, María de Lourdes. (2013). "hFixL-FxkR are the key regulators for fixKf-related gene expression". Mexican Journal of Scientific Research. ():-.
2012Zamorano Sánchez, David Salvador, Reyes-González, A., Gómez Hernández, Nicolás, Rivera, P., Georgellis, D., Girard Cuesy, María de Lourdes. (2012). "FxkR Provides the Missing Link in the fixL-fixK Signal Transduction Cascade in Rhizobium etli CFN42". Molecular Plant-Microbe Interactions. 25(11):1506-1517. [doi:10.1094/MPMI-05-12-0136-R]22809273