Rab7: roles in membrane trafficking and disease


By jpeza - Posted on 18 Noviembre 2010

Fecha Publicación: 
1 Ene 2009
Nombre de Revista: 
Datos del paper
Autor Principal: 
Ming ZHANG
Volumen: 
29
Página Inicial: 
193
Página Final: 
209
Abstract: 

The endocytosis pathway controls multiple cellular and physiological events. The lysosome is the destination of
newly synthesized lysosomal hydrolytic enzymes. Internalized molecules or particles are delivered to the lysosome
for degradation through sequential transport along the endocytic pathway. The endocytic pathway is also emerging
as a signalling platform, in addition to the well-known role of the plasma membrane for signalling. Rab7 is a late
endosome-/lysosome-associated small GTPase, perhaps the only lysosomal Rab protein identified to date. Rab7
plays critical roles in the endocytic processes. Through interaction with its partners (including upstream regulators
and downstream effectors), Rab7 participates in multiple regulation mechanisms in endosomal sorting, biogenesis of
lysosome [or LRO (lysosome-related organelle)] and phagocytosis. These processes are closely related to substrates
degradation, antigen presentation, cell signalling, cell survival and microbial pathogen infection. Consistently, mutations
or dysfunctions of Rab7 result in traffic disorders, which cause various diseases, such as neuropathy, cancer
and lipid metabolism disease. Rab7 also plays important roles in microbial pathogen infection and survival, as well
as in participating in the life cycle of viruses. Here, we give a brief review on the central role of Rab7 in endosomal
traffic and summarize the studies focusing on the participation of Rab7 in disease pathogenesis. The underlying
mechanism governed by Rab7 and its partners will also be discussed.

Dirección del Autor: 

Institute for Biomedical Research, Xiamen University, Xiamen, Fujian, 361005, People’s Republic of China

Keywords: 
disease
endocytosis
membrane trafficking
pathogen infection
Rab7
virus
Coautores: 

Li CHEN, Shicong WANG and Tuanlao WANG1

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