The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype).


By jpeza - Posted on 12 Noviembre 2010

Fecha Publicación: 
1 Dic 1982
Nombre de Revista: 
Datos del paper
Autor Principal: 
Caton AJ
Volumen: 
31
Issue: 
parte1
Página Inicial: 
417
Página Final: 
427
Abstract: 

We have constructed an operational antigenic map of the hemagglutinin of
influenza virus A/PR/8/34, which indicates the presence of five
immunodominant antigenic regions exhibiting various degrees of
operational linkage. These sites have been located by the identification
of changed amino acid residues in mutant viruses that are antigenically
altered at each site. Comparison of the antigenic features with the
three-dimensional structure of the H3 subtype hemagglutinin shows that
the antigenic sites correspond to four topographically distinct regions
of the surface of the protein. One of the sites is formed when two
regions that are widely separated in the hemagglutinin monomer associate
in the assembled trimer. The location of the sites relative to those
proposed for the H3 subtype hemagglutinin suggests that carbohydrate
modulates the antigenicity of specific regions of the hemagglutinin.

Dirección del Autor: 

Sir William Dunn School of Pathology University of Oxford South Parks Road Oxford OX1 3RE, England

Keywords: 
influenza virus A/PR/8/34 ; hemagglutinin (H1 subtype)
Coautores: 
Brownlee GG, Yewdell JW, Gerhard W.
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