Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS

By jpeza - Posted on 09 Julio 2009

Fecha Publicación: 
1 Ene 1998
Nombre de Revista: 
Datos del paper
Autor Principal: 
Mengsheng Qiua
Página Inicial: 
Página Final: 

Here we report the isolation, sequence and developmental expression in the central nervous system of several members of the chicken

and mouse Nkx gene family. These are among the earliest genes to be regionally expressed in the neural plate; they are expressed just above

the axial mesendoderm (prechordal mesendoderm and notochord). Each Nkx gene has a distinct spatial pattern of expression along theanterior-posterior axis of the ventral central nervous system:

Nkx-2.2 is expressed along the entire axis, whereas Nkx-2.1 is restricted to the

forebrain, and Nkx-6.1 and Nkx-6.2 are largely excluded from the forebrain. They are also expressed in distinct patterns along the dorsalventralaxis. These genes are expressed in both the ventricular and mantle zones; in the mantle zone

Nkx-6.1 is co-expressed with Islet-1 in

a subset of motor neurons. Like other Nkx genes, expression of Nkx-6.1 is induced by the axial mesendoderm and by sonic hedgehogprotein. BMP-7 represses

Nkx-6.1 expression. While the notochord can induce Nkx-6.1 expression in the anterior neural plate, sonic hedgehog protein does not, suggesting that the notochord produces additional molecules that can regulate ventral patterning. Ó 1998

Elsevier Science Ireland Ltd.

Dirección del Autor: 

aDepartment of Anatomy and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA

bNara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-01, Japan

cNina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in

Neuroscience and Developmental Biology, 401 Parnassus Avenue, University of California at San Francisco, San Francisco, CA 94143-0984, USA

Nkx; Neural plate; Neural tube; Patterning; Sonic hedgehog

Kenji Shimamurab,1, Lori Susselc, Sandy Chenc, John L.R. Rubensteinc

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