Mechanisms of Protection Against Rotavirus Infection and Disease


By jpeza - Posted on 07 Julio 2009

Fecha Publicación: 
1 Ene 2009
Datos del paper
Autor Principal: 
Richard Ward
Volumen: 
28
Issue: 
suplemento 3
Página Inicial: 
S57
Página Final: 
S59
Abstract: 

Rotavirus is a double-stranded RNA virus composed of 3

protein layers. These layers contain structural proteins (eg, VP4, VP6, and

VP7) that are involved in the induction of immunity. Despite extensive

research in animal models and humans, the mechanisms and effectors of

protection against rotavirus after either natural infection or vaccination

remain unclear. Complicating factors include the variety of immunologic

responses produced after both natural infection and vaccination, and the

fact that animal models do not fully mimic the human immunologic

responses, even when inoculated with homologous rotaviruses. Nevertheless,

it appears that neutralizing antibodies have a role in protection against

rotavirus infection and disease, but that other effectors, such as nonneutralizing

antibodies and T cells, have important effector properties as

well. These effectors likely have overlapping functions, thus providing

enhanced protection. The results of further research to elucidate the

immunologic mechanism of protection will provide insight into improving

the efficacy of current vaccines.

Dirección del Autor: 

From the Cincinnati Children’s Hospital Medical Center, University of Cincinnati,

Cincinnati, OH.

Keywords: 
Reoviridae
rotavirus
gastroenteritis
rotavirus vaccine
AdjuntoTamaño
[file] Pediatric_infectious_ disease_journal_2009_vol28_supl3_pp S57-59.pdf236.25 KB