Transcriptional regulation in bacterial membrane lipid synthesis

By jpeza - Posted on 29 Junio 2009

Fecha Publicación: 
1 Ene 2009
Nombre de Revista: 
Datos del paper
Autor Principal: 
Yong-Mei Zhang
suplemento 2009
Página Inicial: 
pp S115
Página Final: 
S 119

This review covers the main transcriptional mechanisms

that control membrane phospholipid synthesis in

bacteria. The fatty acid components are the most energetically

expensive modules to produce; thus, the regulation

of fatty acid production is very tightly controlled to match

the growth rate of cells. Gram-negative and Gram-positive

bacteria have evolved different structural classes of regulators

to control the genes required for fatty acid biosynthesis.

Also, there are other transcriptional regulators that allow the

cells to alter the structure of fatty acids in existing phospholipid

molecules or to modify the structures of exogenous

fatty acids prior to their incorporation into the bilayer.

A major thrust for future research in this area is the identification

of the ligands or effectors that control the DNA binding

activity of the transcriptional regulators of fatty acid

biosynthesis. With the exception of malonyl-CoA regulation

of FapR from Bacillus subtilis and long-chain acyl-CoA regulation

of FadR from Escherichia coli and DesT from Pseudomonasaeruginosa

, the identity of these intracellular regulators remains unknown.Zhang, Y-M., and C. O. Rock. Transcriptional

regulation in bacterial membrane lipid synthesis.

J. Lipid Res. 2009. 50: S115S119.

Dirección del Autor: 

Department of Infectious Diseases, St. Jude Childrenʼs Research Hospital, Memphis, TN 38105

bacteria ; fatty acid ; phospholipid ; desaturase

Charles O. Rock

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