Colibacillosis in poultry: unravelling the molecular basis of


By jpeza - Posted on 28 Mayo 2009

Fecha Publicación: 
1 Ene 2008
Nombre de Revista: 
Datos del paper
Autor Principal: 
Francis Dziva
Volumen: 
37
Issue: 
4
Página Inicial: 
355
Página Final: 
366
Abstract: 

Avian colibacillosis is caused by a group of pathogens designated avian pathogenic Escherichia coli (APEe).

Despite being known for over a century, avian colibacillosis remains one of the majar endemic diseases

affiicting the poultry industry worldwide. Autologous bacterins provide limited serotype-specific protection,

yet multiple serogroups are associated with disease, especially 01, 02 and 078 among many others.

Experimental infection models have facilitated the identification of some key APEC virulence gene s and

have allowed testing ofvaccine candidates. Well-recognized virulence factors indude Type 1 (FI) and P (Pap/

Prs) fimbriae for colonization, IbeA for invasion, iron acquisition systems, TraT and Iss for serum survival,

K and O antigens for anti-phagocytic activity, and a temperature-sensitive haemagglutinin of imprecise

function. Intriguingly, these factors do not occur universally among APEC, suggesting the presence of

multiple alternative mechanisms mediating pathogenicity. The recent availability of the first complete APEC

genome sequence can be expected to accelerate the identification of bacterial genes expressed during

infection and required for virulence. High-throughput molecular approaches like signature-tagged

transposon mutagenesis have already proved invaluable in revealing portfolios of gene s expressed by

pathogenic bacteria during infection, and this has enabled identification of APEC 02 factors required for

septicaemia in the chicken model. Complimentary approaches, such as in vivo-induced antigen technology,

exist to define the activities of APEC in vivo. In recent years, reverse vaccinology and immuno-proteomic

approaches have also enabled identification of novel vaccine candidates in other bacterial pathogens.

Collectively, such information provides the basis for the development or improvement of strategies to control

APEC infections in the food-producing avian species.

Dirección del Autor: 

Division of Microbiology, ¡nstilule for Animal Health, Complon, Newbury, Berkshire RG20 7NN, UK

Keywords: 
Escherichia coli ; avian pathogenic
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