Quorum sensing by 2-alkyl-4-quinolones


By jpeza - Posted on 26 Mayo 2009

Nombre de Revista: 
Datos del paper
Autor Principal: 
Stephen P. Diggle
Volumen: 
4
Issue: 
9
Página Inicial: 
873
Página Final: 
956
Abstract: 

Pseudomonas aeruginosa produces the cell-to-cell signal molecule 2-heptyl-3-hydroxy-4-quinolone (The Pseudomonas quinolone signal; PQS), which is integrated within a

complicated quorum sensing signaling system. PQS belongs to the family of 2-alkyl-4-

quinolones (AQs), which have been previously described for their antimicrobial activities.

PQS is synthesized via the pqsABCDE operon which is responsible for generating multiple

AQs including 2-heptyl-4-quinolone (HHQ), the immediate PQS precursor. In addition,

PQS signaling plays an important role in P. aeruginosa pathogenesis because it regulates

the production of diverse virulence factors including elastase, pyocyanin and LecA lectin

in addition to affecting biofilm formation. Here, we summarize the most recent findings

on the biosynthesis and regulation of PQS and other AQs including the discovery of AQs

in other bacterial species

Keywords: 
Pseudomonas aeruginosa ; bacterial species.
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