The Genetic Structure and History of Africans and African Americans

By jpeza - Posted on 22 Mayo 2009

Fecha Publicación: 
22 May 2009
Nombre de Revista: 
Datos del paper
Autor Principal: 
Sarah A. Tishkoff
Página Inicial: 
Página Final: 

Africa is the source of all modern humans, but characterization of genetic variation and of

relationships among populations across the continent has been enigmatic. We studied 121 African

populations, four African American populations, and 60 non-African populations for patterns of

variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral

population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or

linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting

historical migration events across the continent. Our data also provide evidence for shared ancestry

among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The

ancestry of African Americans is predominantly from Niger-Kordofanian (~71%), European

(~13%), and other African (~8%) populations, although admixture levels varied considerably

among individuals. This study helps tease apart the complex evolutionary history of Africans and

African Americans, aiding both anthropological and genetic epidemiologic studies.

genetic variation ; Genetic of population ; Africa

Sarah A. Tishkoff,1,2,* Floyd A. Reed,1,{dagger},{ddagger} Françoise R. Friedlaender,3,{ddagger} Christopher Ehret,4 Alessia Ranciaro,1,2,5,§ Alain Froment,6,§ Jibril B. Hirbo,1,2 Agnes A. Awomoyi,1,|| Jean-Marie Bodo,7 Ogobara Doumbo,8 Muntaser Ibrahim,9 Abdalla T. Juma,9 Maritha J. Kotze,10 Godfrey Lema,11 Jason H. Moore,12 Holly Mortensen,1, Thomas B. Nyambo,11 Sabah A. Omar,13 Kweli Powell,1,# Gideon S. Pretorius,14 Michael W. Smith,15 Mahamadou A. Thera,8 Charles Wambebe,16 James L. Weber,17 Scott M. Williams18

[file] Science_2009_Vol. 324_ no. 5930_ pp. 1035 - 1044.pdf6.22 MB