Isabel María López Lara

Ecología Genómica Investigador

Inv. Tit. B T.C. Definitivo

Semblanza

Isabel María López Lara estudió biología en la Universidad de Granada, en Granada (España). Obtuvo su título de doctora en 1992 por la Universidad de Granada con el trabajo “Estudio genético y bioquímico de los polisacáridos de superficie de Rhizobium sp GRH2” realizado en la Estación Experimental del Zaidín (Consejo Superior de Investigaciones Científicas) bajo la supervisión de Nicolás Toro García. De 1993 a 1995 realizó estudios postdoctorales con Herman P. Spaink en el “Institute of Molecular Plant Sciences” en Leiden (Países Bajos) estudiando la base molecular de la interacción Rhizobium-legumionosa Posteriormente, con una beca EMBO (European Molecular Biology Organization), realizó estudios postdoctorales con Otto Geiger en el Departamento de Biotecnología de la Universidad Técnica de Berlín (Alemania) en donde estudió biosíntesis de lípidos en rizobios. En octubre de 1999 se integró como investigadora al entonces Centro de Investigación sobre Fijación de Nitrógeno (CIFN) de la Universidad Nacional Autónoma de México (UNAM). Su investigación se enfoca en estudiar el metabolismo de ácidos grasos en bacterias, incluyendo su biosíntesis, modificaciones de los mismos para dar lugar a moléculas señal y su transferencia a otras moléculas durante la formación de lípidos de membrana. Es Investigador titular B, investigador nacional nivel II y pertenece al PRIDE con el nivel C. Fue editor asociado de la revista Molecular Plant-Microbe Interactions de Estados Unidos en el periodo 2004-2006.

Ligas

Scopus

Teléfono: (777) 3131697
Correo: isabel@ccg.unam.mx

Publicaciones

AñoPublicaciónPMID
2017López-Lara, I.M., Geiger, O. (2017) Bacterial lipid diversity Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids 1862(11):1287-1299 [doi:10.1016/j.bbalip.2016.10.007]27760387
2017Angel Vences-Guzman, Miguel, Goetting-Minesky, M. Paula, Guan, Ziqiang, Castillo-Ramirez, Santiago, America Cordoba-Castro, Luz, Lopez-Lara, Isabel M., Geiger, Otto, Sohlenkamp, Christian, Fenno, J. Christopher (2017) 1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway Molecular Microbiology 103(5):896-912 [doi:10.1111/mmi.13596]28009086
2016Sahonero-Canavesi, Diana X., Zavaleta-Pastor, Maritza, Martinez-Aguilar, Lourdes, Lopez-Lara, Isabel M., Geiger, Otto (2016) Defining Substrate Specificities for Lipase and Phospholipase Candidates JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (117):e54613- [doi:10.3791/54613]27911408
2015Escobedo-Hinojosa, W.I., Vences-Guzmán, M.Á., Schubotz, F., Sandoval-Calderón, M., Summons, R.E., López-Lara, I.M., Geiger, O., Sohlenkamp, C. (2015) OlsG (Sinac-1600) Is an ornithine lipid N-Methyltransferase from the planctomycete Singulisphaera acidiphila Journal Of Biological Chemistry 290(24):15102-15111 [doi:10.1074/jbc.M115.639575]25925947
2015Sahonero-Canavesi, D.X., Sohlenkamp, C., Sandoval-Calderón, M., Lamsa, A., Pogliano, K., López-Lara, I.M., Geiger, O. (2015) Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase Environmental Microbiology 17(9):3391-3406 [doi:10.1111/1462-2920.12814]25711932
2013Geiger, O, Lopez-Lara, IM, Sohlenkamp, C (2013) Phosphatidylcholine biosynthesis and function in bacteria Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids 1831(3, SI):503-513 [doi:10.1016/j.bbalip.2012.08.009]22922101
2012Estrada De Los Santos, Paulina, Martínez Aguilar, Lourdes, López Lara, Isabel María, Caballero Mellado, José de Jesús (2012) Cupriavidus alkaliphilus sp nov., a new species associated with agricultural plants that grow in alkaline soils Systematic And Applied Microbiology 35(5):310-314 [doi:10.1016/j.syapm.2012.05.005]22738764
2011Pech Canul, Angel De La Cruz, Nogales, J., Miranda-Molina, A., Álvarez, L., Geiger, Otto, Soto, M.J., López Lara, Isabel María (2011) FadD Is Required for Utilization of Endogenous Fatty Acids Released from Membrane Lipids Journal Of Bacteriology 193(22):6295-6304 [doi:10.1128/JB.05450-11]21926226
2011González Silva, Napoleón, López Lara, Isabel María, Reyes-Lamothe, R., Taylor, A.M., Sumpton, D., Thomas-Oates, J., Geiger, Otto (2011) The Dioxygenase-Encoding olsD Gene from Burkholderia cenocepacia Causes the Hydroxylation of the Amide-Linked Fatty Acyl Moiety of Ornithine-Containing Membrane Lipids Biochemistry 50(29):6396-6408 [doi:10.1021/bi200706v]21707055
2011Vences Guzmán, Miguel Ángel, Guan, Z.Q., Ormeño Orrillo, Ernesto Aldo, González Silva, Napoleón, López Lara, Isabel María, Martínez Romero, María Esperanza, Geiger, Otto, Sohlenkamp, Christian (2011) Hydroxylated ornithine lipids increase stress tolerance in Rhizobium tropici CIAT899 Molecular Microbiology 79(6):1496-1514 [doi:10.1111/j.1365-2958.2011.07535.x]21205018
2010Medeot, Daniela B., Sohlenkamp, Christian, Dardanelli, Marta S., Geiger, Otto, Garcia de Lema, Mirta, Lopez-Lara, Isabel M. (2010) Phosphatidylcholine levels of peanut-nodulating Bradyrhizobium sp SEMIA 6144 affect cell size and motility Fems Microbiology Letters 303(2):123-131 [doi:10.1111/j.1574-6968.2009.01873.x]20030724
2010Zavaleta-Pastor, Maritza, Sohlenkamp, Christian, Gao, Jun-Lian, Guan, Ziqiang, Zaheer, Rahat, Finan, Turlough M., Raetz, Christian R. H., Lopez-Lara, Isabel M., Geiger, Otto (2010) Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107(1):302-307 [doi:10.1073/pnas.0912930107]20018679
2010Geiger, Otto, Sohlenkamp, Christian, López Lara, Isabel María (2010) Formation of bacterial membrane lipids: pathways, enzymes, reactions Handbook of Hydrocarbon and Lipid Microbiology Hydrocarbons, Oils, and Lipids: Diversity, Properties and Formation ():396-405
2010López Lara, Isabel María, Geiger, Otto (2010) Formation of fatty acids Handbook of Hydrocarbon and Lipid Microbiology Hydrocarbons, Oils, and Lipids: Diversity, Properties and Formation ():385-394
2010Davila-Martinez, Yadira, Laura Ramos-Vega, Ana, Contreras-Martinez, Sandra, Encarnacion, Sergio, Geiger, Otto, Lopez-Lara, Isabel M. (2010) SMc01553 is the sixth acyl carrier protein in Sinorhizobium meliloti 1021 MICROBIOLOGY-SGM 156(1):230-239 [doi:10.1099/mic.0.033480-0]19797355
2010Geiger, Otto, Gonzalez-Silva, Napoleon, Lopez-Lara, Isabel M., Sohlenkamp, Christian (2010) Amino acid-containing membrane lipids in bacteria Progress In Lipid Research 49(1):46-60 [doi:10.1016/j.plipres.2009.08.002]19703488
2009Laura Ramos-Vega, Ana, Davila-Martinez, Yadira, Sohlenkamp, Christian, Contreras-Martinez, Sandra, Encarnacion, Sergio, Geiger, Otto, Lopez-Lara, Isabel M. (2009) SMb20651 is another acyl carrier protein from Sinorhizobium meliloti MICROBIOLOGY-SGM 155(Pt 1):257-267 [doi:10.1099/mic.0.022079-0]19118366
2008Sepulveda, E., Perez-Mendoza, D., Ramirez-Romero, M. A., Soto, M. J., Lopez-Lara, I. M., Geiger, O., Sanjuan, J., Brom, S., Romero, D. (2008) Modulation of conjugative activity of rhizobial symbiotic plasmids by repression and transcriptional interference FEBS JOURNAL 275(1):49-49
2008Sepulveda, Edgardo, Perez-Mendoza, Daniel, Ramirez-Romero, Miguel A., Soto, Maria J., Lopez-Lara, Isabel M., Geiger, Otto, Sanjuan, Juan, Brom, Susana, Romero, David (2008) Transcriptional interference and repression modulate the conjugative ability of the symbiotic plasmid of Rhizobium etli Journal Of Bacteriology 190(12):4189-4197 [doi:10.1128/JB.00041-08]18424522
2008Geiger, Otto, López Lara, Isabel María, Sohlenkamp, Christian (2008) Altered formations of special eubacterial membrane lipids affect bacterial interactions with eukaryotic hosts Current Plant Science and Biotechnology. Agriculture Biological Nitrogen Fixation, Sustainable Agriculture and the Environment 42(0):245-246
2007Sepulveda, Edgardo, Perez-Mendoza, Daniel, Munoz, Socorro, Ramirez-Romero, Miguel A., Soto, Maria Jose, Cervantes, Laura, Herrera-Cervera, Jose A., Lopez-Lara, Isabel Sabel, Geiger, Otto, Sanuan, Juan, Brom, Susana, Romero, David (2007) Regulation of conjugal transfer of the Rhizobium etli Sym plasmid. Plasmid 57(2):220-221
2007Medeot, D.B., Sohlenkamp, Christian, Geiger, Otto, García, M.B., López Lara, Isabel María (2007) Phosphatidycholine fuction in rhizobial strains nodulating peanut: genes and enzymatic activites BIOCELL 31():134-
2006Sánchez, F., Quinto, C., López Lara, Isabel María, Geiger, Otto (2006) Biology of Plant-Microbe Interactions Proceedings of the 12th International Congress on Molecular Plant-Microbe Interactions 5():1-717
2006Geiger, Otto, Sohlenkamp, Christian, López Lara, Isabel María (2006) Function of rhizobial membrane lipids for the symbiosis with legumes Proceedings of the 12th International Congress on Molecular Plant-Microbe Interactions 5():132-137
2006López Lara, Isabel María, Sohlenkamp, Christian, Geiger, Otto (2006) The post-genomic era - What comes next? Revista latinoamericana de microbiología 48(1):44-4517357573
2005Lopez-Lara, IM, Gao, JL, Soto, MJ, Solares-Perez, A, Weissenmayer, B, Sohlenkamp, C, Verroios, GP, Thomas-Oates, J, Geiger, O (2005) Phosphorus-free membrane lipids of Sinorhizobium meliloti are not required for the symbiosis with alfalfa but contribute to increased cell yields under phosphorus-limiting conditions of growth Molecular Plant-Microbe Interactions 18(9):973-982 [doi:10.1094/MPMI-18-0973]16167767
2004Sepulveda, Edgardo, Perez-Mendoza, Daniel, Munoz, Socorro, Ramirez-Romero, Miguel A., Soto, Maria Jose, Cervantes, Laura, Herrera-Cervera, Jose A., Lopez-Lara, Isabel Sabel, Geiger, Otto, Sanuan, Juan, Brom, Susana, Romero, David (2004) Identification of functional mob regions in Rhizobium etli: Evidence for self-transmissibility of the symbiotic plasmid pRetCFN42d Journal Of Bacteriology 186(17):5753-5761 [doi:10.1128/JB.186.17.5753-5761.2004]15317780
2004Gao, JL, Weissenmayer, B, Taylor, AM, Thomas-Oates, J, Lopez-Lara, IM, Geiger, O (2004) Identification of a gene required for the formation of lyso-ornithine lipid, an intermediate in the biosynthesis of ornithine-containing lipids Molecular Microbiology 53(6):1757-1770 [doi:10.1111/j.1365-2958.2004.04240.x]15341653
2004Geiger, O, Sohlenkamp, C, Martinez-Morales, F, Gao, JL, Zavaleta-Pastor, M, Lopez-Lara, IM (2004) Regulation of membrane lipid biosynthesis in eubacteria FASEB JOURNAL 18(8, S):3-3
2003Martinez-Morales, F, Schobert, M, Lopez-Lara, IM, Geiger, O (2003) Pathways for phosphatidylcholine biosynthesis in bacteria MICROBIOLOGY-SGM 149(12):3461-3471 [doi:10.1099/mic.0.26522-0]14663079
2003Lopez-Lara, IM, Sohlenkamp, C, Geiger, O (2003) Membrane lipids in plant-associated bacteria: Their biosyntheses and possible functions Molecular Plant-Microbe Interactions 16(7):567-579 [doi:10.1094/MPMI.2003.16.7.567]12848422
2003Sohlenkamp, C, Lopez-Lara, IM, Geiger, O (2003) Biosynthesis of phosphatidylcholine in bacteria Progress In Lipid Research 42(2):115-162 [doi:10.1016/S0163-7827(02)00050-4]12547654
2002Weissenmayer, B, Gao, JL, Lopez-Lara, IM, Geiger, O (2002) Identification of a gene required for the biosynthesis of ornithine-derived lipids Molecular Microbiology 45(3):721-733 [doi:10.1046/j.1365-2958.2002.03043.x]12139618
2002Geiger, Otto, López Lara, Isabel María (2002) Rhizobial acyl carrier proteins and their roles in the formation of bacterial cell-surface components that are required for the development of nitrogen-fixing root nodules on legume hosts Fems Microbiology Letters 208(2):153-162 [doi:10.1016/S0378-1097(02)00478-0]11959430
2001Lopez-Lara, IM, Geiger, O (2001) Novel pathway for phosphatidylcholine biosynthesis in bacteria associated with eukaryotes Journal Of Biotechnology 91(2-3, SI):211-221 [doi:10.1016/S0168-1656(01)00331-5]11566392
2001Lopez-Lara, IM, Geiger, O (2001) The nodulation protein NodG shows the enzymatic activity of an 3-oxoacyl-acyl carrier protein reductase Molecular Plant-Microbe Interactions 14(3):349-357 [doi:10.1094/MPMI.2001.14.3.349]11277432
2000de Rudder, KEE, Lopez-Lara, IM, Geiger, O (2000) Inactivation of the gene for phospholipid N-methyltransferase in Sinorhizobium meliloti: phosphatidylcholine is required for normal growth Molecular Microbiology 37(4):763-772 [doi:10.1046/j.1365-2958.2000.02032.x]10972799
2000Sohlenkamp, C, de Rudder, KEE, Rohrs, V, Lopez-Lara, IM, Geiger, O (2000) Cloning and characterization of the gene for phosphatidylcholine synthase Journal Of Biological Chemistry 275(25):18919-18925 [doi:10.1074/jbc.M000844200]10858449
2000Castillo, P, Marquez, J, Rubluo, A, Hernandez, G, Lara, M (2000) Plant regeneration from callus and suspension cultures of Valeriana edulis ssp procera via simultaneous organogenesis and somatic embryogenesis Plant Science 151(2):115-119 [doi:10.1016/S0168-9452(99)00203-4]10808067