José Utrilla Carreri

Systems Biology and Synthetic Biology Laboratory Researcher

Assistant Professor

Academic history

Dr. José Utrilla Carreri is a Biochemical Engineer, he did a PhD in the metabolic engineering group of the IBt-UNAM. He is an expert in metabolic engineering, systems and synthetic biology.
He has developed bacterial production strains and applied in bioprocesses at pilot scale with the collaboration of Mexican companies. He carried out a posdoctoc at the systems biology research group (SBRG) at University of California in San Diego under Prof. Bernhard O. Palsson supervision, there he studied the genotype-phenotype relations in laboratory evolved Escherichia coli strains using genome-scale computational modeling. On november 2014 he started a position as a Associated Researcher in the UNAM Center for Genomic Sciences. He is a member of the national researcher sistem (Level I), and he is a professor in the Genomic Sciences undergraduate program, a tutor in the Biomedical Sciences graduate program and he is currently supervising bachelors, masters and doctorate thesis. Dr. Utrilla´s specific research topics include the design of genome scale computational tools to guide the optimization of microbial cell factories. The design of synthetic phenotypes through the engineering of the regulatory network. The engineering of the Escherichia coli´s transcription and translation machinery to allocate cellular resources to synthetic biology applications. Dr. Jose Utrilla is also involved in several collaborations to develop new bacterial production chassis, multiscale synthetic biology applications and alternative carbon source utilization for sustainable biobased chemical production.


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Telephone: (777) 3291686


2017Moreno-Avitia, F., Lozano, L, Utrilla, J, Bolívar, F. and Escalante, A.. (2017). "Draft genome sequence of pseudomonas chlororaphis ATCC 9446, a nonpathogenic bacterium with bioremediation and industrial potential". Genome Announcements. 5(23):e00474-17-. [doi:10.1128/genomeA.00474-17]28596401
2016Utrilla, J, Vargas-Tah, Alejandra, Trujillo-Martinez, Berenice, Gosset, Guillermo and Martinez, Alfredo. (2016). "Production of D-lactate from sugarcane bagasse and corn stover hydrolysates using metabolic engineered Escherichia coli strains". BIORESOURCE TECHNOLOGY. 220():208-214. [doi:10.1016/j.biortech.2016.08.067]27573474
2016O'Brien EJ, Utrilla, J and Palsson BO. (2016). "Quantification and Classification of E. coli Proteome Utilization and Unused Protein Costs across Environments". Plos Computational Biology. 12(6):e1004998-. [doi:10.1371/journal.pcbi.1004998]27351952
2018Latif, H., Federowicz, S., Ebrahim, A., Tarasova, J., Szubin, R., Utrilla, J, Zengler, K. and Palsson, B.O.. (2018). "ChIP-exo interrogation of Crp, DNA, and RNAP holoenzyme interactions". Plos One. 13(5):e0197272-. [doi:10.1371/journal.pone.0197272]29771928
2017Steffani-Vallejo, J.L., Zuñiga, C., Cruz-Morales, P., Lozano, L, Morales, M., Licona-Cassani, C., Revah, S. and Utrilla, J. (2017). "Draft genome sequence of Sphingobacterium sp. CZ-UAM, isolated from a methanotrophic consortium". Genome Announcements. 5(33):e00792-17-. [doi:10.1128/genomeA.00792-17]28818899
2017Utrilla, J. (2017). "Evolutionary Engineering of Microorganisms to Overcome Toxicity During Lignocellulose Hydrolysates Utilization". Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources. ():181-200. [doi:]
2016Utrilla, J, O'Brien, E.J., Chen, K., McCloskey, D., Cheung, J., Wang, H., Armenta-Medina, D., Feist, A.M. and Palsson, B.O.. (2016). "Global Rebalancing of Cellular Resources by Pleiotropic Point Mutations Illustrates a Multi-scale Mechanism of Adaptive Evolution". Cell systems. 2(4):260-271. [doi:10.1016/j.cels.2016.04.003]27135538