Isabel María López Lara

Ecological Genomics Researcher

Associate Professor

Academic history

Isabel M. López-Lara studied biology at the University of Granada, in Granada, Spain. She received her doctoral title from the University of Granada in 1992 with the work “Genetic and biochemical studies of surface polysaccharides of Rhizobium sp. GRH2″ that she carried out in the Estación Experimental del Zaidín, Granada, Spanish Council for Scientific Research (CSIC) under the supervision of Nicolás Toro García. From 1993 to 1995, she did postdoctoral work in Leiden (The Netherlands) at the Institute of Molecular Plant Sciences with Herman P. Spaink on the “Molecular basis of the Rhizobium-legume interaction” with fellowships from the Spanish Ministry and the European Community. Subsequently, as an EMBO fellow, she did postdoctoral work in the Department of Biotechnology at the Technical University of Berlin, Germany, working on “Lipid biosynthesis in Rhizobia” with Otto Geiger. She currently holds the position of Assistant Professor (Investigador Titular B) at the Center for Genomic Sciences (formerly the Research Center for Nitrogen Fixation) at the National Autonomous University of Mexico (Cuernavaca) which she joined in 1999. Presently she studies the metabolism of fatty acids in bacteria, including their biosynthesis, modifications to form signal molecules, and transfer of fatty acids during the formation of membrane lipids. She was Associate Editor for the Journal Molecular Plant-Microbe Interactions for the period 2004-2006.

Links

Scopus

Telephone: (777) 3131697
Email: isabel@ccg.unam.mx

Publications

YearPublicationPMID
2017López-Lara, I.M., Geiger, O. (2017) Bacterial lipid diversity Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids 1862(11):1287-1299 [doi:10.1016/j.bbalip.2016.10.007]27760387
2017Angel Vences-Guzman, Miguel, Goetting-Minesky, M. Paula, Guan, Ziqiang, Castillo-Ramirez, Santiago, America Cordoba-Castro, Luz, Lopez-Lara, Isabel M., Geiger, Otto, Sohlenkamp, Christian, Fenno, J. Christopher (2017) 1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway Molecular Microbiology 103(5):896-912 [doi:10.1111/mmi.13596]28009086
2016Sahonero-Canavesi, Diana X., Zavaleta-Pastor, Maritza, Martinez-Aguilar, Lourdes, Lopez-Lara, Isabel M., Geiger, Otto (2016) Defining Substrate Specificities for Lipase and Phospholipase Candidates JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (117):e54613- [doi:10.3791/54613]27911408
2015Escobedo-Hinojosa, W.I., Vences-Guzmán, M.Á., Schubotz, F., Sandoval-Calderón, M., Summons, R.E., López-Lara, I.M., Geiger, O., Sohlenkamp, C. (2015) OlsG (Sinac-1600) Is an ornithine lipid N-Methyltransferase from the planctomycete Singulisphaera acidiphila Journal Of Biological Chemistry 290(24):15102-15111 [doi:10.1074/jbc.M115.639575]25925947
2015Sahonero-Canavesi, D.X., Sohlenkamp, C., Sandoval-Calderón, M., Lamsa, A., Pogliano, K., López-Lara, I.M., Geiger, O. (2015) Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase Environmental Microbiology 17(9):3391-3406 [doi:10.1111/1462-2920.12814]25711932
2013Geiger, O, Lopez-Lara, IM, Sohlenkamp, C (2013) Phosphatidylcholine biosynthesis and function in bacteria Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids 1831(3, SI):503-513 [doi:10.1016/j.bbalip.2012.08.009]22922101
2012Estrada De Los Santos, Paulina, Martínez Aguilar, Lourdes, López Lara, Isabel María, Caballero Mellado, José de Jesús (2012) Cupriavidus Alkaliphilus sp nov., a new species associated with agricultural plants that grow in alkaline soils Systematic And Applied Microbiology 35(5):310-314 [doi:10.1016/j.syapm.2012.05.005]22738764
2011Pech Canul, Angel De La Cruz, Nogales, J., Miranda-Molina, A., Álvarez, L., Geiger, Otto, Soto, M.J., López Lara, Isabel María (2011) FadD Is Required for Utilization of Endogenous Fatty Acids Released from Membrane Lipids Journal Of Bacteriology 193(22):6295-6304 [doi:10.1128/JB.05450-11]21926226
2011Vences Guzmán, Miguel Ángel, Guan, Z.Q., Ormeño Orrillo, Ernesto Aldo, González Silva, Napoleón, López Lara, Isabel María, Martínez Romero, María Esperanza, Geiger, Otto, Sohlenkamp, Christian (2011) Hydroxylated ornithine lipids increase stress tolerance in Rhizobium tropici CIAT899 Molecular Microbiology 79(6):1496-1514 [doi:10.1111/j.1365-2958.2011.07535.x]21205018
2010Zavaleta-Pastor, Maritza, Sohlenkamp, Christian, Gao, Jun-Lian, Guan, Ziqiang, Zaheer, Rahat, Finan, Turlough M., Raetz, Christian R. H., Lopez-Lara, Isabel M., Geiger, Otto (2010) Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107(1):302-307 [doi:10.1073/pnas.0912930107]20018679
2010Medeot, Daniela B., Sohlenkamp, Christian, Dardanelli, Marta S., Geiger, Otto, Garcia de Lema, Mirta, Lopez-Lara, Isabel M. (2010) Phosphatidylcholine levels of peanut-nodulating Bradyrhizobium sp SEMIA 6144 affect cell size and motility Fems Microbiology Letters 303(2):123-131 [doi:10.1111/j.1574-6968.2009.01873.x]20030724
2010Geiger, Otto, Sohlenkamp, Christian, López Lara, Isabel María (2010) Formation of bacterial membrane lipids: pathways, enzymes, reactions Handbook of Hydrocarbon and Lipid Microbiology Hydrocarbons, Oils, and Lipids: Diversity, Properties and Formation ():396-405
2010López Lara, Isabel María, Geiger, Otto (2010) Formation of fatty acids Handbook of Hydrocarbon and Lipid Microbiology Hydrocarbons, Oils, and Lipids: Diversity, Properties and Formation ():385-394
2010Davila-Martinez, Yadira, Laura Ramos-Vega, Ana, Contreras-Martinez, Sandra, Encarnacion, Sergio, Geiger, Otto, Lopez-Lara, Isabel M. (2010) SMc01553 is the sixth acyl carrier protein in Sinorhizobium meliloti 1021 MICROBIOLOGY-SGM 156(1):230-239 [doi:10.1099/mic.0.033480-0]19797355
2010Geiger, Otto, Gonzalez-Silva, Napoleon, Lopez-Lara, Isabel M., Sohlenkamp, Christian (2010) Amino acid-containing membrane lipids in bacteria Progress In Lipid Research 49(1):46-60 [doi:10.1016/j.plipres.2009.08.002]19703488
2009Laura Ramos-Vega, Ana, Davila-Martinez, Yadira, Sohlenkamp, Christian, Contreras-Martinez, Sandra, Encarnacion, Sergio, Geiger, Otto, Lopez-Lara, Isabel M. (2009) SMb20651 is another acyl carrier protein from Sinorhizobium meliloti MICROBIOLOGY-SGM 155(Pt 1):257-267 [doi:10.1099/mic.0.022079-0]19118366
2008Sepulveda, E., Perez-Mendoza, D., Ramirez-Romero, M. A., Soto, M. J., Lopez-Lara, I. M., Geiger, O., Sanjuan, J., Brom, S., Romero, D. (2008) Modulation of conjugative activity of rhizobial symbiotic plasmids by repression and transcriptional interference FEBS JOURNAL 275(1):49-49
2008Sepulveda, Edgardo, Perez-Mendoza, Daniel, Ramirez-Romero, Miguel A., Soto, Maria J., Lopez-Lara, Isabel M., Geiger, Otto, Sanjuan, Juan, Brom, Susana, Romero, David (2008) Transcriptional interference and repression modulate the conjugative ability of the symbiotic plasmid of Rhizobium etli Journal Of Bacteriology 190(12):4189-4197 [doi:10.1128/JB.00041-08]18424522
2008Geiger, Otto, López Lara, Isabel María, Sohlenkamp, Christian (2008) Altered formations of special eubacterial membrane lipids affect bacterial interactions with eukaryotic hosts Current Plant Science and Biotechnology. Agriculture Biological Nitrogen Fixation, Sustainable Agriculture and the Environment 42(0):245-246
2007Sepulveda, Edgardo, Perez-Mendoza, Daniel, Munoz, Socorro, Ramirez-Romero, Miguel A., Soto, Maria Jose, Cervantes, Laura, Herrera-Cervera, Jose A., Lopez-Lara, Isabel Sabel, Geiger, Otto, Sanuan, Juan, Brom, Susana, Romero, David (2007) Regulation of conjugal transfer of the Rhizobium etli Sym plasmid. Plasmid 57(2):220-221
2007Medeot, D.B., Sohlenkamp, Christian, Geiger, Otto, García, M.B., López Lara, Isabel María (2007) Phosphatidycholine fuction in rhizobial strains nodulating peanut: genes and enzymatic activites BIOCELL 31():134-
2007Medeot, D.B., Sohlenkamp, Christian, Geiger, Otto, García, M.B., López Lara, Isabel María (2007) Phosphatidycholine fuction in rhizobial strains nodulating peanut: genes and enzymatic activites Biocell 31():134-
2006Sánchez, F., Quinto, C., López Lara, Isabel María, Geiger, Otto (2006) Biology of Plant-Microbe Interactions Proceedings of the 12th International Congress on Molecular Plant-Microbe Interactions 5():1-717
2006Geiger, Otto, Sohlenkamp, Christian, López Lara, Isabel María (2006) Function of rhizobial membrane lipids for the symbiosis with legumes Proceedings of the 12th International Congress on Molecular Plant-Microbe Interactions 5():132-137
2006López Lara, Isabel María, Sohlenkamp, Christian, Geiger, Otto (2006) The post-genomic era - What comes next? Revista latinoamericana de microbiología 48(1):44-4517357573
2005Lopez-Lara, IM, Gao, JL, Soto, MJ, Solares-Perez, A, Weissenmayer, B, Sohlenkamp, C, Verroios, GP, Thomas-Oates, J, Geiger, O (2005) Phosphorus-free membrane lipids of Sinorhizobium meliloti are not required for the symbiosis with alfalfa but contribute to increased cell yields under phosphorus-limiting conditions of growth Molecular Plant-Microbe Interactions 18(9):973-982 [doi:10.1094/MPMI-18-0973]16167767
2004Gao, JL, Weissenmayer, B, Taylor, AM, Thomas-Oates, J, Lopez-Lara, IM, Geiger, O (2004) Identification of a gene required for the formation of lyso-ornithine lipid, an intermediate in the biosynthesis of ornithine-containing lipids Molecular Microbiology 53(6):1757-1770 [doi:10.1111/j.1365-2958.2004.04240.x]15341653
2004Sepulveda, Edgardo, Perez-Mendoza, Daniel, Munoz, Socorro, Ramirez-Romero, Miguel A., Soto, Maria Jose, Cervantes, Laura, Herrera-Cervera, Jose A., Lopez-Lara, Isabel Sabel, Geiger, Otto, Sanuan, Juan, Brom, Susana, Romero, David (2004) Identification of functional mob regions in Rhizobium etli: Evidence for self-transmissibility of the symbiotic plasmid pRetCFN42d Journal Of Bacteriology 186(17):5753-5761 [doi:10.1128/JB.186.17.5753-5761.2004]15317780
2003Martinez-Morales, F, Schobert, M, Lopez-Lara, IM, Geiger, O (2003) Pathways for phosphatidylcholine biosynthesis in bacteria MICROBIOLOGY-SGM 149(12):3461-3471 [doi:10.1099/mic.0.26522-0]14663079
2003Lopez-Lara, IM, Sohlenkamp, C, Geiger, O (2003) Membrane lipids in plant-associated bacteria: Their biosyntheses and possible functions Molecular Plant-Microbe Interactions 16(7):567-579 [doi:10.1094/MPMI.2003.16.7.567]12848422
2003Sohlenkamp, C, Lopez-Lara, IM, Geiger, O (2003) Biosynthesis of phosphatidylcholine in bacteria Progress In Lipid Research 42(2):115-162 [doi:10.1016/S0163-7827(02)00050-4]12547654
2002Geiger, Otto, López Lara, Isabel María (2002) Rhizobial acyl carrier proteins and their roles in the formation of bacterial cell-surface components that are required for the development of nitrogen-fixing root nodules on legume hosts Fems Microbiology Letters 208(2):153-162 [doi:10.1016/S0378-1097(02)00478-0]11959430
2002Weissenmayer, B, Gao, JL, Lopez-Lara, IM, Geiger, O (2002) Identification of a gene required for the biosynthesis of ornithine-derived lipids Molecular Microbiology 45(3):721-733 [doi:10.1046/j.1365-2958.2002.03043.x]12139618
2001Lopez-Lara, IM, Geiger, O (2001) Novel pathway for phosphatidylcholine biosynthesis in bacteria associated with eukaryotes Journal Of Biotechnology 91(2-3, SI):211-221 [doi:10.1016/S0168-1656(01)00331-5]11566392
2001Lopez-Lara, IM, Geiger, O (2001) The nodulation protein NodG shows the enzymatic activity of an 3-oxoacyl-acyl carrier protein reductase Molecular Plant-Microbe Interactions 14(3):349-357 [doi:10.1094/MPMI.2001.14.3.349]11277432
2000de Rudder, KEE, Lopez-Lara, IM, Geiger, O (2000) Inactivation of the gene for phospholipid N-methyltransferase in Sinorhizobium meliloti: phosphatidylcholine is required for normal growth Molecular Microbiology 37(4):763-772 [doi:10.1046/j.1365-2958.2000.02032.x]10972799
2000Sohlenkamp, C, de Rudder, KEE, Rohrs, V, Lopez-Lara, IM, Geiger, O (2000) Cloning and characterization of the gene for phosphatidylcholine synthase Journal Of Biological Chemistry 275(25):18919-18925 [doi:10.1074/jbc.M000844200]10858449
2011González Silva, Napoleón, López Lara, Isabel María, Reyes-Lamothe, R., Taylor, A.M., Sumpton, D., Thomas-Oates, J., Geiger, Otto (2011) The Dioxygenase-Encoding olsD Gene from Burkholderia cenocepacia Causes the Hydroxylation of the Amide-Linked Fatty Acyl Moiety of Ornithine-Containing Membrane Lipids Biochemistry 50(29):6396-6408 [doi:10.1021/bi200706v]21707055
2004Geiger, O, Sohlenkamp, C, Martinez-Morales, F, Gao, JL, Zavaleta-Pastor, M, Lopez-Lara, IM (2004) Regulation of membrane lipid biosynthesis in eubacteria FASEB JOURNAL 18(8, S):3-3
2000Castillo, P, Marquez, J, Rubluo, A, Hernandez, G, Lara, M (2000) Plant regeneration from callus and suspension cultures of Valeriana edulis ssp procera via simultaneous organogenesis and somatic embryogenesis Plant Science 151(2):115-119 [doi:10.1016/S0168-9452(99)00203-4]10808067