Georgina Hernández Delgado

Functional Genomics of Eukaryotes Researcher

Full Professor

Academic history

Georgina Hernández received her undergraduate (biochemistry and molecular biology) and PhD (molecular biology) degrees from the National University of México (UNAM). During her studies she performed research on the regulation of nitrogen / carbon metabolism of the model fungus Neurospora crassa, under the supervision of Jaime Mora. She did a postdoctoral training (1986-1988) as a Visiting Scientist in BioTechnica International, Inc., Agricultural Biotechnology Department (Cambridge, MA, USA) headed by Frank Cannon. During her sabbatical leave from UNAM (2005-2006) she performed research at the University of Minnesota – USDA, Department of Agronomy and Plant Genetics, and at the Max-Planck-Institute for Molecular Plant Physiology (Golm, Germany) collaborating as a visiting scientist in the groups of Carroll P. Vance and Michael Udvardi, respectively.

She currently holds the position of Professor (Investigador Titular C) at the Center for Genomic Sciences (CCG), formerly the Nitrogen Fixation Research Center (CIFN) from UNAM (Cuernavaca, México). She was hired as faculty of the Center since 1983. She has served as the Director of the Center from 1997 to 2005. She has served UNAM in multiple evaluating committees, as member of different university councils and as coordinator of teaching programs. Currently she serves as Head of the Eukaryotic Functional Genomics Research Program from CCG – UNAM. She is a member of the Mexican Academy of Sciences and has served this institution as Treasurer (2014-2017).

Since almost 30 years ago she has performed research in the area of Plant Biology, related to nitrogen metabolism and, mainly, to the nitrogen-fixing symbiosis (SNF) of legume plants with the Rhizobia soil bacteria. Current research from her group, in collaboration with colleagues from different countries, is focused in the SNF of common bean (Phaseolus vulgaris) that is the main legume for human consumption in the world. Her pioneer work contributed to the development the functional genomic of P. vulgaris, namely transcriptomics and metabolomics. Using these approaches she investigates different levels of the regulation of gene expression in SNF common bean, including transcriptional and post-transcriptional levels to decipher novel global regulators of the symbiosis such as transcriptional factors, microRNAs and the role of alternative splicing. Her scientific contributions have been published in more than 50 articles in international journals, have received more than 2,000 citations in the literature (H index = 24) and are recognized by colleagues form her research area.

Since the beginning of her career she has taught courses in undergraduate and graduate programs and has contributed in the formation of new scientists as advisor of post-doctors and graduate students.

Telephone: (777) 3290864


2018Martin-Rodriguez, Jose A., Leija, Alfonso, Formey, Damien, Hernandez, Georgina (2018) The MicroRNA319d/TCP10 Node Regulates the Common Bean - Rhizobia Nitrogen-Fixing Symbiosis Frontiers In Plant Science 9():1175-1175 [doi:10.3389/fpls.2018.01175]30147704
2017Ortiz-Berrocal, Marlene, Lozano, Luis, Sanchez-Flores, Alejandro, Nava, Noreide, Hernandez, Georgina, Reddy, Pallavolu M. (2017) Expression in rice of an autoactive variant of Medicago truncatula DMI3, the Ca+2/calmodulin-dependent protein kinase from the common symbiotic pathway modifies root transcriptome and improves mycorrhizal colonization PLANT BIOTECHNOLOGY REPORTS 11(5):271-287 [doi:10.1007/s11816-017-0449-4]
2016Formey D, Martín-Rodríguez JÁ, Leija A, Santana O, Quinto C, Cárdenas L, Hernández G (2016) Regulation of Small RNAs and Corresponding Targets in Nod Factor-Induced Phaseolus vulgaris Root Hair Cells International Journal Of Molecular Sciences 17(6):887- [doi:10.3390/ijms17060887]27271618
2016Ramirez, Mario, Iniguez, Luis P., Guerrero, Gabriela, Sparvoli, Francesca, Hernandez, Georgina (2016) Rhizobium etli bacteroids engineered for Vitreoscilla hemoglobin expression alleviate oxidative stress in common bean nodules that reprogramme global gene expression PLANT BIOTECHNOLOGY REPORTS 10(6):463-474 [doi:10.1007/s11816-016-0422-7]
2015Íñiguez LP, Nova-Franco B, Hernández G (2015) Novel players in the AP2-miR172 regulatory network for common bean nodulation PLANT SIGNALING & BEHAVIOR 10(10):UNSP e1062957- [doi:10.1080/15592324.2015.1062957]26211831
2015Formey, Damien, Pedro Iniguez, Luis, Pelaez, Pablo, Li, Yong-Fang, Sunkar, Ramanjulu, Sanchez, Federico, Luis Reyes, Jose, Hernandez, Georgina (2015) Genome-wide identification of the Phaseolus vulgaris sRNAome using small RNA and degradome sequencing Bmc Genomics 16():423-423 [doi:10.1186/s12864-015-1639-5]26059339
2015Nova-Franco B, Íñiguez LP, Valdés-López O, Alvarado-Affantranger X, Leija A, Fuentes SI, Ramírez M, Paul S, Reyes JL, Girard L, Hernández G (2015) The Micro-RNA172c-APETALA2-1 Node as a Key Regulator of the Common Bean-Rhizobium etli Nitrogen Fixation Symbiosis Plant Physiology 168(1):273-502 [doi:10.1104/pp.114.255547]25739700
2015Valdes-Lopez, Oswaldo, Hernandez, Georgina (2015) Early Responses in the Root-Rhizobia Interaction Plant Microbe Interactions 75():137-147 [doi:10.1016/bs.abr.2015.07.003]
2014O'Rourke, Jamie A., Iniguez, Luis P., Fu, Fengli, Bucciarelli, Bruna, Miller, Susan S., Jackson, Scott A., McClean, Philip E., Li, Jun, Dai, Xinbin, Zhao, Patrick X., Hernandez, Georgina, Vance, Carroll P. (2014) An RNA-Seq based gene expression atlas of the common bean Bmc Genomics 15():866-866 [doi:10.1186/1471-2164-15-866]25283805
2014Naya Aquilué, Loreto, Paul, Sujay, Valdes-López, O., Mendoza Soto, Ana Belén, Nova Franco, Bárbara, Sosa-Valencia, G., Reyes, J.L., Hernández Delgado, Georgina (2014) Regulation of Copper Homeostasis and Biotic Interactions by MicroRNA 398b in Common Bean Plos One 9(1):84416- [doi:10.1371/journal.pone.0084416]24400089
2014Garcia-Garcia, J.D., Girard Cuesy, María de Lourdes, Hernández Delgado, Georgina, Saavedra, E., Pardo, J.P., Rodríguez-Zavala, J.S., Encalada, R., Reyes-Prieto, A., Mendoza-Cozatl, D.G., Moreno-Sánchez, R. (2014) Zn-bis-glutathionate is the best co-substrate of the monomeric phytochelatin synthase from the photosynthetic heavy metal-hyperaccumulator Euglena Gracilis Metallomics 6(3):604-616 [doi:10.1039/c3mt00313b]24464102
2013Ramírez Yáñez, Mario, Guillén, G., Fuentes Membreño, Sara Isabel, Iñiguez Rabago, Luis Pedro, Aparicio Fabre, Rosaura, Zamorano Sánchez, David Salvador, Encarnación Guevara, Sergio Manuel, Panzeri, D., Castiglioni, B., Cremonesi, P., Strozzi, F., Stella, A., Girard Cuesy, María de Lourdes, Sparvoli, F., Hernández Delgado, Georgina (2013) Transcript profiling of common bean nodules subjected to oxidative stress Physiologia Plantarum 149(3):389-407 [doi:10.1111/ppl.12040]23432573
2013Ramírez Yáñez, Mario, Flores-Pacheco, G., Reyes, J.L., Álvarez, A.L., Drevon, J.J., Girard Cuesy, María de Lourdes, Hernández Delgado, Georgina (2013) Two Common Bean Genotypes with Contrasting Response to Phosphorus Deficiency Show Variations in the microRNA 399-Mediated PvPHO2 Regulation within the PvPHR1 Signaling Pathway International Journal Of Molecular Sciences 14(4):8328-8344 [doi:10.3390/ijms14048328]23591845
2013Galindo Fentanes, E., Sánchez Castillo, J., Calva Mercado, E., Cuevas García, S., Davis Martínez, O., Larralde Ridaura, H., Iturriaga de la Fuente, G., Hernández Delgado, Georgina (2013) La Ciencia desde Morelos para el Mundo Tomo III: Química, Física y Matemáticas La Unión de Morelos ():-
2012García-García, J.D., Olin-Sandoval, V., Saavedra, E., Girard Cuesy, María de Lourdes, Hernández Delgado, Georgina, Moreno-Sánchez, R. (2012) Sulfate uptake in photosynthetic Euglena Gracilis. Mechanisms of regulation and contribution to cysteine homeostasis Biochimica Et Biophysica Acta-General Subjects 1820(10):1567-1575 [doi:10.1016/j.bbagen.2012.05.002]22609877
2012Estivill, G., Betti, M., Guardado, P., Maestre, A., Arellano, J, Hernandez, G, Márquez, A.J., Galván, F. (2012) Functional analysis of site-directed mutants from the active site of higher plant glutamine synthetase FEBS JOURNAL 279(1, SI):458-458
2010Yang, S. Samuel, Valdes-Lopez, Oswaldo, Xu, Wayne W., Bucciarelli, Bruna, Gronwald, John W., Hernandez, Georgina, Vance, Carroll P. (2010) Transcript profiling of common bean (Phaseolus vulgaris L.) using the GeneChip (R) Soybean Genome Array: optimizing analysis by masking biased probes Bmc Plant Biology 10():85-85 [doi:10.1186/1471-2229-10-85]20459672
2010Valdes-Lopez, Oswaldo, Yang, S. Samuel, Aparicio-Fabre, Rosaura, Graham, Peter H., Luis Reyes, Jose, Vance, Carroll P., Hernandez, Georgina (2010) MicroRNA expression profile in common bean (Phaseolus vulgaris) under nutrient deficiency stresses and manganese toxicity New Phytologist 187(3):805-818 [doi:10.1111/j.1469-8137.2010.03320.x]20553393
2010Ortiz, Anabel, Cardoso-Taketa, Alexandre, Rodriguez Monroy, Mario, Arellano, Jesus, Hernandez, Georgina, Luisa Villarreal, Maria (2010) Transformed Cell Suspension Culture of Galphimia Glauca Producing Sedative Nor-friedelanes Planta Medica 76(4):386-392 [doi:10.1055/s-0029-1186166]19809970
2010Valdes López, Oswaldo, Graham, P.H., Ramírez Yáñez, Mario, Udvardi, M.K., Reyes, J.L., Vance, C.P., Hernández Delgado, Georgina (2010) Transcriptional and post-transcriptional regulation in common bean nodules Biology of Plant-Microbe Interactions 7():-
2009Hernandez, Georgina, Valdes-Lopez, Oswaldo, Ramirez, Mario, Goffard, Nicolas, Weiller, Georg, Aparicio-Fabre, Rosaura, Isabel Fuentes, Sara, Erban, Alexander, Kopka, Joachim, Udvardi, Michael K., Vance, Carroll P. (2009) Global Changes in the Transcript and Metabolic Profiles during Symbiotic Nitrogen Fixation in Phosphorus-Stressed Common Bean Plants Plant Physiology 151(3):1221-1238 [doi:10.1104/pp.109.143842]19755543
2009Arellano, Jesus, Fuentes, Sara Isabel, Castillo-Espana, Patricia, Hernandez, Georgina (2009) Regeneration of different cultivars of common bean (Phaseolus vulgaris L.) via indirect organogenesis Plant Cell Tissue And Organ Culture 96(1):11-18 [doi:10.1007/s11240-008-9454-1]
2008Valdes-Lopez, Oswaldo, Arenas-Huertero, Catalina, Ramirez, Mario, Girard, Lourdes, Sanchez, Federico, Vance, Carroll P., Reyes, Jose Luis, Hernandez, Georgina (2008) Essential role of MYB transcription factor: PvPHR1 and microRNA: PvmiR399 in phosphorus-deficiency signalling in common bean roots Plant Cell And Environment 31(12):1834-1843 [doi:10.1111/j.1365-3040.2008.01883.x]18771575
2008Valdes-Lopez, Oswaldo, Hernandez, Georgina (2008) Transcriptional regulation and signaling in phosphorus starvation: What about legumes? Journal Of Integrative Plant Biology 50(10):1213-1222 [doi:10.1111/j.1744-7909.2008.00758.x]19017108
2008Suarez, Ramon, Wong, Arnoldo, Ramirez, Mario, Barraza, Aaron, Orozco, Maria del Carmen, Cevallos, Miguel A., Lara, Miguel, Hernandez, Georgina, Iturriaga, Gabriel (2008) Improvement of drought tolerance and grain yield in common bean by overexpressing trehalose-6-phosphate synthase in Rhizobia Molecular Plant-Microbe Interactions 21(7):958-966 [doi:10.1094/MPMI-21-7-0958]18533836
2008Gepts, P., Aragao, F., de Barros, E., Blair, M.W., Brodani, R., Broughton, W.J., Galasso, I., Hernández Delgado, Georgina, Kami, J., Lariguet, P., McClean, P., Melotto, M., Miklas, P., Pauls, P., Pedrosa-Harand, A., Porch, T., Sánchez Solano, Erika Fabiola, Sparvoli, F., Yu, K. (2008) Genomics of Phaseolus beans, a major source of dietary protein and micronutrients in the tropics. Genomics of tropical crop plants (0):113-143
2007Hernandez, Georgina, Ramirez, Mario, Valdes-Lopez, Oswaldo, Tesfaye, Mesfin, Graham, Michelle A., Czechowski, Tomasz, Schlereth, Armin, Wandrey, Maren, Erban, Alexander, Cheung, Foo, Wu, Hank C., Lara, Miguel, Town, Christopher D., Kopka, Joachim, Udvardi, Michael K., Vance, Carroll P. (2007) Phosphorus stress in common bean: Root transcript and metabolic responses Plant Physiology 144(2):752-767 [doi:10.1104/pp.107.096958]17449651
2006Graham, Michelle A., Ramirez, Mario, Valdes-Lopez, Oswaldo, Lara, Miguel, Tesfaye, Mesfin, Vance, Carroll P., Hernandez, Georgina (2006) Identification of candidate phosphorus stress induced genes in Phaseolus vulgaris through clustering analysis across several plant species FUNCTIONAL PLANT BIOLOGY 33(8):789-797 [doi:10.1071/FP06101]
2006Lara Flores, Miguel, Blanco López, María de Lourdes, Silvente Keller, Sonia Teresa, Graham, M.A., Ramírez Romero, Miguel Ángel, Reddy, Pallavolu Maheswara, Hernández Delgado, Georgina, Vance, C. (2006) Genomic approaches for analysis of legume-Rhizobium symbiotic interactions and nodule metabolism in bean (Phaseolus vulgaris) Proceedings of the 12th International Congress on Molecular Plant-Microbe Interactions 5(0):138-143
2005Ramirez, M, Graham, MA, Blanco-Lopez, L, Silvente, S, Medrano-Soto, A, Blair, MW, Hernandez, G, Vance, CP, Lara Flores, Miguel (2005) Sequencing and analysis of common bean ESTs. Building a foundation for functional genomics Plant Physiology 137(4):1211-1227 [doi:10.1104/pp.104.054999]15824284
2003Guo, XW, Flores, M, Mavingui, P, Fuentes, SI, Hernandez, G, Davila, G, Palacios, R (2003) Natural genomic design in Sinorhizobium meliloti novel genomic architectures GENOME RESEARCH 13(8):1810-1817 [doi:10.1101/gr.1260903]12902376
2003Broughton, WJ, Hernandez, G, Blair, M, Beebe, S, Gepts, P, Vanderleyden, J (2003) Beans (Phaseolus spp.) - model food legumes PLANT AND SOIL 252(1):55-128 [doi:10.1023/A:1024146710611]
2003Cordoba, E, Shishkova, S, Vance, CP, Hernandez, G (2003) Antisense inhibition of NADH glutamate synthase impairs carbon/nitrogen assimilation in nodules of alfalfa (Medicago sativa L.) PLANT JOURNAL 33(6):1037-1049 [doi:10.1046/j.1365-313X.2003.01686.x]12631328
2003Suarez, R, Marquez, J, Shishkova, S, Hernandez, G (2003) Overexpression of alfalfa cytosolic glutamine synthetase in nodules and flowers of transgenic Lotus japonicus plants Physiologia Plantarum 117(3):326-336 [doi:10.1034/j.1399-3054.2003.00053.x]12654032
2002Castillo, P, Zamilpa, A, Marquez, J, Hernandez, G, Lara Flores, Miguel, Alvarez, L (2002) Comparative study of differentiation levels and valepotriate content of in vitro cultures and regenerated and wild plants of Valeriana edulis ssp procera JOURNAL OF NATURAL PRODUCTS 65(4):573-575 [doi:10.1021/np0104267]11975504
2001Chichkova, S, Arellano, J, Vance, CP, Hernandez, G (2001) Transgenic tobacco plants that overexpress alfalfa NADH-glutamate synthase have higher carbon and nitrogen content Journal Of Experimental Botany 52(364):2079-2087 [doi:10.1093/jexbot/52.364.2079]11604446
2001Fuentes, SI, Allen, DJ, Ortiz-Lopez, A, Hernandez, G (2001) Over-expression of cytosolic glutamine synthetase increases photosynthesis and growth at low nitrogen concentrations Journal Of Experimental Botany 52(358):1071-1081 [doi:10.1093/jexbot/52.358.1071]11432923
2000Flores, M, Mavingui, P, Perret, X, Broughton, WJ, Romero, D, Hernandez, G, Davila, G, Palacios, R (2000) Prediction, identification, and artificial selection of DNA rearrangements in Rhizobium: Toward a natural genomic design PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(16):9138-9143 [doi:10.1073/pnas.97.16.9138]10922070
2000Schoenbeck, MA, Temple, SJ, Trepp, GB, Blumenthal, JM, Samac, DA, Gantt, JS, Hernandez, G, Vance, CP (2000) Decreased NADH glutamate synthase activity in nodules and flowers of alfalfa (Medicago sativa L.) transformed with an antisense glutamate synthase transgene Journal Of Experimental Botany 51(342):29-39 [doi:10.1093/jexbot/51.342.29]10938793
1999Ramirez, M, Valderrama, B, Arredondo-Peter, R, Soberon, M, Mora, J, Hernandez, G (1999) Rhizobium etli genetically engineered for the heterologous expression of Vitreoscilla sp. hemoglobin: Effects on free-living and symbiosis Molecular Plant-Microbe Interactions 12(11):1008-1015 [doi:10.1094/MPMI.1999.12.11.1008]
1999Castillo, M, Flores, M, Mavingui, P, Martinez-Romero, E, Palacios, R, Hernandez, G (1999) Increase in alfalfa nodulation, nitrogen fixation, and plant growth by specific DNA amplification in Sinorhizobium meliloti Applied And Environmental Microbiology 65(6):2716-272210347066
1997Chichkova, S, Arellano, J, Svoboda, S, Hernandez, G (1997) Ectopic overexpression of NADH-glutamate synthase in transgenic tobacco modifies plant response to excess of ammonium. Plant Physiology 114(3, S):911-911
1996Arellano, J, Vazquez, F, Villegas, T, Hernandez, G (1996) Establishment of transformed root cultures of Perezia cuernavacana producing the sesquiterpene quinone perezone PLANT CELL REPORTS 15(7):455-45824178452
1995Mendoza Herrera, Alberto, Leija Salas, Alfonso, Martínez Romero, María Esperanza, Hernández Delgado, Georgina, Mora Celis, Jaime (1995) The enhancement of ammonium assimilation in Rhizobium etli prevents nodulation of Phaseolus vulgaris Molecular Plant-Microbe Interactions 8(4):584-592 [doi:10.1094/MPMI-8-0584]8589413
1993FUENTES, SI, SUAREZ, R, VILLEGAS, T, ACERO, LC, HERNANDEZ, G (1993) EMBRYOGENIC RESPONSE OF MEXICAN ALFALFA (Medicago-sativa) VARIETIES Plant Cell Tissue And Organ Culture 34(3):299-302 [doi:10.1007/BF00029720]
1986HERNANDEZ, G, MORA, J (1986) Glutamine synthesis regulates sucrose catabolism in Neurospora crassa Journal Of General Microbiology 132(12):3315-3323
1986HERNANDEZ, G, MORA, Y, MORA, J (1986) Regulation of glutamine synthesis by glycine and serine in Neurospora crassa Journal Of Bacteriology 165(1):133-138 [doi:10.1128/jb.165.1.133-138.1986]2867084
1983Hernandez, G, Sánchez-Pescador, R., PALACIOS, R, MORA, J (1983) Nitrogen source regulates glutamate dehydrogenase NADP synthesis in Neurospora crassa Journal Of Bacteriology 154(1):524-5286300039
2000Castillo, P, Marquez, J, Rubluo, A, Hernandez, G, Lara, M (2000) Plant regeneration from callus and suspension cultures of Valeriana edulis ssp procera via simultaneous organogenesis and somatic embryogenesis Plant Science 151(2):115-119 [doi:10.1016/S0168-9452(99)00203-4]10808067
2013Aparicio Fabre, Rosaura, Guillén, G., Loredo, M., Arellano García, José de Jesús, Valdes López, Oswaldo, Ramírez Yáñez, Mario, Iñiguez Rabago, Luis Pedro, Panzeri, D., Castiglioni, B., Cremonesi, P., Strozzi, F., Stella, A., Girard Cuesy, María de Lourdes, Sparvoli, F., Hernández Delgado, Georgina (2013) Common bean (Phaseolus vulgaris L.) PvTIFY orchestrates global changes in transcript profile response to jasmonate and phosphorus deficiency Bmc Plant Biology 13():26-26 [doi:10.1186/1471-2229-13-26]23402340
2018Chiozzotto, Remo, Ramirez, Mario, Talbi, Chouhra, Cominelli, Eleonora, Girard, Lourdes, Sparvoli, Francesca, Hernandez, Georgina (2018) Characterization of the symbiotic nitrogen-fixing common bean Low phytic acid (Lpa1) mutant response to water stress Genes 9(2):99- [doi:10.3390/genes9020099]29462877
2017Iñiguez LP, Ramírez M, Barbazuk WB, Hernández G (2017) Identification and analysis of alternative splicing events in Phaseolus vulgaris and Glycine max Bmc Genomics 18(1):650-650 [doi:10.1186/s12864-017-4054-2]28830361
1987MORA, Y, HERNANDEZ, G, MORA, J (1987) Regulation of carbon and nitrogen flow by glutamate synthase in Neurospora crassa Journal Of General Microbiology 133(7):1667-1674 [doi:10.1099/00221287-133-7-1667]2959749
2017Iniguez, Luis P., Hernandez, Georgina (2017) The Evolutionary Relationship between Alternative Splicing and Gene Duplication Frontiers in Genetics 8():14-14 [doi:10.3389/fgene.2017.00014]28261262
2015Mendoza-Soto AB, Naya L, Leija A, Hernández G (2015) Responses of symbiotic nitrogen-fixing common bean to aluminum toxicity and delineation of nodule responsive microRNAs Frontiers In Plant Science 6():587-587 [doi:10.3389/fpls.2015.00587]26284103
2013O'Rourke, J.A., Iñiguez Rabago, Luis Pedro, Bucciarelli, B., Roessler, J., Schmutz, J., McClean, P.E., Jackson, S.A., Hernández Delgado, Georgina, Graham, M.A., Stupar, R.M., Vance, C.P. (2013) A re-sequencing based assessment of genomic heterogeneity and fast neutron-induced deletions in a common be an cultivar Frontiers In Plant Science 4():210-210 [doi:10.3389/fpls.2013.00210]23805147
2012Mendoza Soto, Ana Belén, Sánchez, F., Hernández Delgado, Georgina (2012) MicroRNAs as regulators in plant metal toxicity response Frontiers In Plant Science 3():105-105 [doi:10.3389/fpls.2012.00105]22661980