Christian Sohlenkamp

Ecological Genomics Researcher

Associate Professor

Academic history

Christian Sohlenkamp studied biotechnology at the Technical University of Berlin, Germany. His diploma thesis was titled “Phosphatidylcholine synthase in Rhizobia“. He did his doctoral studies at the Max-Planck-Institute for Molecular Plant Physiology in Golm, Germany , about the mechanisms of ammonium transport in Arabidopsis thaliana under the supervision of Michael Udvardi. He received his doctoral title from the Technical University of Berlin in 2001. As a Feodor-Lynen Fellow of the Alexander von Humboldt Foundation, he did postdoctoral work in Mexico at the Nitrogen Fixation Center (CIFN) of the National Autonomous University of Mexico (UNAM) with Otto Geiger working on the role of bacterial cell surfaces in the pathogenic and symbiotic interactions between bacteria and eukaryotic hosts. He currently holds the position of an Assistant Professor (Investigador Titular B) at the Center for Genomic Sciences (formerly CIFN) at the UNAM (Campus Morelos, Cuernavaca).. Christian Sohlenkamp was crucially involved in the discovery of the phosphatidylcholine synthase pathway which constitutes a major route for phosphatidylcholine formation in bacteria and he was the first to describe the AMT2 family of ammonium transporters in plants.
The focus of his work is on the biosynthesis, turnover and degradation of bacterial membrane lipids. He is also interested how changes in the composition of the lipid bilayer affect the resistance of the bacteria to abiotic stress and the interactions with eukaryotic hosts. Ongoing projects include “Function of ornithine lipids in Vibrio Cholerae“, “Understanding the acid stress response in Rhizobium tropici“, “New pathways for synthesis and hydroxylation of ornithine lipids”, and “Modulating membrane properties and phenotypes of bacteria by combinatorial engineering of ornithine lipids”. For their research the group uses, but also develops tools of microbiology, molecular biology, biochemistry and genomics.
He is Associate Editor of the journal Frontiers in Microbiology- Microbial Physiology and Metabolism and he is Editorial Board Member of the Journal of Biological Chemistry.

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Selected publications

1. Sohlenkamp, C., and O. Geiger. 2016. Bacterial membrane lipids: Diversity in structures and pathways. FEMS Microbiology Reviews. 40:133-59.
2. Vences-Guzmán, M.A., Guan, Z., Escobedo-Hinojosa, W.I., Bermúdez-Barrientes, J.R., Geiger, O., and C. Sohlenkamp. 2015. Discovery of a bifunctional acyltransferase responsible for ornithine lipid synthesis in Serratia Proteamaculans. Environmental Microbiology. 17:1487-1496.
3. Vences-Guzmán, M. Á., Guan, Z., Ormeño-Orrillo, E., González-Silva, N., López-Lara, I. M., Martínez-Romero, E., Geiger, O., and C. Sohlenkamp. 2011. Hydroxylated ornithine lipids increase stress tolerance in Rhizobium tropici CIAT899. Mol. Microbiol. 79:1496-1514.
4. Sohlenkamp, C., M. Shelden, S. Howitt, and M. Udvardi. 2000.
Characterization of Arabidopsis AtAMT2, a novel ammonium transporter in plants. FEBS Lett. 467:273-278.
5. Sohlenkamp, C., K. E. E. de Rudder, V. Röhrs, I. M. López-Lara, and O. Geiger. 2000. Cloning and characterization of the gene for phosphatidylcholine synthase. J. Biol. Chem. 275:18919-18925.

Telephone: (777) 3131697
Email: chsohlen@ccg.unam.mx

Publications

YearPublicationPMID
2018Hölzl G, Sohlenkamp, C, Vences-Guzmán, MA and Gisch N. (2018). "Headgroup hydroxylation by OlsE occurs at the C4 position of ornithine lipid and is widespread in proteobacteria and bacteroidetes.". CHEM PHYS LIPIDS. 213():32-38. [doi:10.1016/j.chemphyslip.2018.03.002]29524395
2017Sandoval-Calderón M, Guan Z and Sohlenkamp, C. (2017). "Knowns and unknowns of membrane lipid synthesis in streptomycetes". Biochimie. 141():21-29. [doi:10.1016/j.biochi.2017.05.008]28522365
2017Vences-Guzmán, MA, Goetting-Minesky, M. Paula, Guan, Ziqiang, Castillo-Ramirez, S, America Cordoba-Castro, Luz, López-Lara, IM, Geiger, O, Sohlenkamp, C and Fenno, J. Christopher. (2017). "1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway". Molecular Microbiology. 103(5):896-912. [doi:10.1111/mmi.13596]28009086
2016Wang, Mingxun, Carver, Jeremy J., Phelan, Vanessa V., Sanchez, Laura M., Garg, Neha, Peng, Yao, Don Duy Nguyen, Watrous, Jeramie, Kapono, Clifford A., Luzzatto-Knaan, Tal, Porto, Carla, Bouslimani, Amina, Melnik, Alexey V., Meehan, Michael J., Liu, Wei -Ting, Criisemann, Max, Boudreau, Paul D., Esquenazi, Eduardo, Sandoval-Calderon, Mario, Kersten, Roland D., Pace, Laura A., Quinn, Robert A., Duncan, Katherine R., Hsu, Cheng-Chih, Floros, Dimitrios J., Gavilan, Ronnie G., Kleigrewe, Karin, Northen, Trent, Dutton, Rachel J., Parrot, Delphine, Carlson, Erin E., Aigle, Bertrand, Michelsen, Charlotte F., Jelsbak, Lars, Sohlenkamp, C, Pevzner, Pavel, Edlund, Anna, McLean, Jeffrey, Piel, Jorn, Murphy, Brian T., Gerwick, Lena, Liaw, Chih-Chuang, Yang, Yu-Liang, Humpf, Hans-Ulrich, Maansson, Maria, Keyzers, Robert A., Sims, Amy C., Johnson, Andrew R., Sidebottom, Ashley M., Sedio, Brian E., Klitgaard, Andreas, Larson, Charles B., Boya P, Cristopher A., Torres-Mendoza, Daniel, Gonzalez, David J., Silva, Denise B., Marques, Lucas M., Demarque, Daniel P., Pociute, Egle, O'Neill, Ellis C., Briand, Enora, Helfrich, Eric J. N., Granatosky, Eve A., Glukhov, Evgenia, Ryffel, Florian, Houson, Hailey, Mohimani, Hosein, Kharbush, Jenan J., Zeng, Yi, Vorholt, Julia A., Kurita, Kenji L., Charusanti, Pep, McPhail, Kerry L., Nielsen, Kristian Fog, Vuong, Lisa, Elfeki, Maryam, Traxler, Matthew F., Engene, Niclas, Koyama, Nobuhiro, Vining, Oliver B., Baric, Ralph, Silva, Ricardo R., Mascuch, Samantha J., Tomasi, Sophie, Jenkins, Stefan, Macherla, Venkat, Hoffman, Thomas, Agarwal, Vinayak, Williams, Philip G., Dai, Jingqui, Neupane, Ram, Gurr, Joshua, Rodriguez, Andres M. C., Lamsa, Anne, Zhang, Chen, Dorrestein, Kathleen, Duggan, Brendan M., Almaliti, Jehad, Allard, Pierre-Marie, Phapale, Prasad, Nothias, Louis-Felix, Alexandrovr, Theodore, Litaudon, Marc, Wolfender, Jean-Luc, Kyle, Jennifer E., Metz, Thomas O., Peryea, Tyler, Dac-Trung Nguyen, VanLeer, Danielle, Shinn, Paul, Jadhav, Ajit, Muller, Rolf, Waters, Katrina M., Shi, Wenyuan, Liu, Xueting, Zhang, Lixin, Knight, Rob, Jensen, Paul R., Palsson, Bernhard O., Pogliano, Kit, Linington, Roger G., Gutierrez, Marcelino, Lopes, Norberto P., Gerwick, William H., Moore, Bradley S., Dorrestein, Pieter C. and Bandeira, Nuno. (2016). "Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking". Nature Biotechnology. 34(8):828-837. [doi:10.1038/nbt.3597]27504778
2015Escobedo-Hinojosa, W.I., Vences-Guzmán, MA, Schubotz, F., Sandoval-Calderón, M., Summons, R.E., López-Lara, IM, Geiger, O and Sohlenkamp, C. (2015). "OlsG (Sinac-1600) Is an ornithine lipid N-Methyltransferase from the planctomycete Singulisphaera acidiphila". JOURNAL OF BIOLOGICAL CHEMISTRY. 290(24):15102-15111. [doi:10.1074/jbc.M115.639575]25925947
2015Sohlenkamp, C and Geiger, O. (2015). "Bacterial membrane lipids: Diversity in structures and pathways". Fems Microbiology Reviews. 40(1):133-159. [doi:10.1093/femsre/fuv008]25862689
2015Sahonero-Canavesi, D.X., Sohlenkamp, C, Sandoval-Calderón, M., Lamsa, A., Pogliano, K., López-Lara, IM and Geiger, O. (2015). "Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase". Environmental Microbiology. 17(9):3391-3406. [doi:10.1111/1462-2920.12814]25711932
2015Vences-Guzmán, MA, Guan, Ziqiang, Itzel Escobedo-Hinojosa, Wendy, Roberto Bermudez-Barrientos, Jose, Geiger, O and Sohlenkamp, C. (2015). "Discovery of a bifunctional acyltransferase responsible for ornithine lipid synthesis in Serratia Proteamaculans". Environmental Microbiology. 17(5):1487-1496. [doi:10.1111/1462-2920.12562]25040623
2014Semeniuk, A., Sohlenkamp, C, Duda, K. and Holzl, G.. (2014). "A Bifunctional Glycosyltransferase from Agrobacterium tumefaciens Synthesizes Monoglucosyl and Glucuronosyl Diacylglycerol under Phosphate Deprivation*". JOURNAL OF BIOLOGICAL CHEMISTRY. 289(14):10104-10114. [doi:10.1074/jbc.M113.519298]24558041
2013Sohlenkamp, C, Raetz, C.R.H. and Ingram, B.O.. (2013). "The calcium-stimulated lipid A 3-O deacylase from Rhizobium etli is not essential for plant nodulation". Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids. 1831(7):1250-1259. [doi:10.1016/j.bbalip.2013.04.002]23583844
2013Vences-Guzmán, MA, Guan, Z.Q., Bermúdez Barrientos, José Roberto, Geiger, O and Sohlenkamp, C. (2013). "Agrobacteria lacking ornithine lipids induce more rapid tumour formation". Environmental Microbiology. 15(3):895-906. [doi:10.1111/j.1462-2920.2012.02867.x]22958119
2013Geiger, O, López-Lara, IM and Sohlenkamp, C. (2013). "Phosphatidylcholine biosynthesis and function in bacteria". Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids. 1831(3):503-513. [doi:10.1016/j.bbalip.2012.08.009]22922101
2012Vences-Guzmán, MA, Geiger, O and Sohlenkamp, C. (2012). "Ornithine lipids and their structural modifications: From A to E and beyond". Fems Microbiology Letters. 335(1):1-10. [doi:10.1111/j.1574-6968.2012.02623.x]22724388
2012Solis Oviedo, Rosa Lidia, Martínez-Morales, F., Geiger, O and Sohlenkamp, C. (2012). "Functional and topological analysis of phosphatidylcholine synthase from Sinorhizobium meliloti". Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids. 1821(4):573-581. [doi:10.1016/j.bbalip.2012.01.016]22333179
2011Sohlenkamp, C. (2011). "Cambios en las membranas bacterianas como respuesta al estrés". Hypatia-A Journal of Feminist Philosophy. 40():-.
2011Vences-Guzmán, MA, Guan, Z.Q., Ormeño Orrillo, Ernesto Aldo, González Silva, Napoleón, López-Lara, IM, Martínez-Romero, E, Geiger, O and Sohlenkamp, C. (2011). "Hydroxylated ornithine lipids increase stress tolerance in Rhizobium tropici CIAT899". Molecular Microbiology. 79(6):1496-1514. [doi:10.1111/j.1365-2958.2011.07535.x]21205018
2010Ingram, Brian O., Sohlenkamp, C, Geiger, O and Raetz, Christian R. H.. (2010). "Altered lipid A structures and polymyxin hypersensitivity of Rhizobium etli mutants lacking the lpxE and LpxF phosphatases". Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids. 1801(5):593-604. [doi:10.1016/j.bbalip.2010.02.001]20153447
2010Medeot, Daniela B., Sohlenkamp, C, Dardanelli, Marta S., Geiger, O, Garcia de Lema, Mirta and López-Lara, IM. (2010). "Phosphatidylcholine levels of peanut-nodulating Bradyrhizobium sp. SEMIA 6144 affect cell size and motility". Fems Microbiology Letters. 303(2):123-131. [doi:10.1111/j.1574-6968.2009.01873.x]20030724
2010Geiger, O, Gonzalez-Silva, Napoleon, López-Lara, IM and Sohlenkamp, C. (2010). "Amino acid-containing membrane lipids in bacteria". Progress In Lipid Research. 49(1):46-60. [doi:10.1016/j.plipres.2009.08.002]19703488
2010Geiger, O, Sohlenkamp, C and López-Lara, IM. (2010). "Formation of bacterial membrane lipids: pathways, enzymes, reactions". Handbook of Hydrocarbon and Lipid Microbiology Hydrocarbons, Oils, and Lipids: Diversity, Properties and Formation. ():396-405.
2008Vences-Guzmán, MA, Geiger, O and Sohlenkamp, C. (2008). "Sinorhizobium meliloti mutants deficient in phosphatidylserine decarboxylase accumulate phosphatidylserine and are strongly affected during symbiosis with Alfalfa". Journal Of Bacteriology. 190(20):6846-6856. [doi:10.1128/JB.00610-08]18708506
2008Geiger, O, López-Lara, IM and Sohlenkamp, C. (2008). "Altered formations of special eubacterial membrane lipids affect bacterial interactions with eukaryotic hosts". Current Plant Science and Biotechnology. Agriculture Biological Nitrogen Fixation, Sustainable Agriculture and the Environment. 42(0):245-246.
2008Geiger, O, López-Lara, IM and Sohlenkamp, C. (2008). "ALTERED FORMATIONS OF SPECIAL EUBACTERIAL MEMBRANE LIPIDS AFFECT BACTERIAL INTERACTIONS WITH EUKARYOTIC HOSTS". Biological Nitrogen Fixation: Towards Poverty Alleviation Through Sustainable Agriculture. 42():245-246.
2008Hacker, Stephanie, Sohlenkamp, C, Aktas, Meriyem, Geiger, O and Narberhaus, Franz. (2008). "Multiple phospholipid N-methyltransferases with distinct substrate specificities are encoded in Bradyrhizobium japonicum". Journal Of Bacteriology. 190(2):571-580. [doi:10.1128/JB.01423-07]17993534
2007Sohlenkamp, C, Galindo-Lagunas, Kanaan A., Guan, Ziqiang, Vinuesa, P, Robinson, Sally, Thomas-Oates, Jane, Raetz, Christian R. H. and Geiger, O. (2007). "The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions". Molecular Plant-Microbe Interactions. 20(11):1421-1430. [doi:10.1094/MPMI-20-11-1421]17977153
2007Medeot, D.B., Sohlenkamp, C, Geiger, O, García, M.B. and López-Lara, IM. (2007). "Phosphatidycholine fuction in rhizobial strains nodulating peanut: genes and enzymatic activites". Biocell. 31():134-.
2006Reeve, Wayne G., Brau, Lambert, Castelli, Joanne, Garau, Giovanni, Sohlenkamp, C, Geiger, O, Dilworth, Michael J., Glenn, Andrew R., Howieson, John G. and Tiwaril, Ravi P.. (2006). "The Sinorhizobium medicae WSM419 IpiA gene is transcriptionally activated by FsrR and required to enhance survival in lethal acid conditions". MICROBIOLOGY-SGM. 152(10):3049-3059. [doi:10.1099/mic.0.28764-0]17005985
2006Geiger, O, Sohlenkamp, C and López-Lara, IM. (2006). "Function of rhizobial membrane lipids for the symbiosis with legumes". Proceedings of the 12th International Congress on Molecular Plant-Microbe Interactions. 5():132-137.
2006López-Lara, IM, Sohlenkamp, C and Geiger, O. (2006). "The post-genomic era - What comes next?". Revista Latinoamericana De Microbiologia. 48(1):44-45. 17357573
2005Rojas-Jimenez, K., Sohlenkamp, C, Geiger, O, Martínez-Romero, E, Werner, D. and Vinuesa, P. (2005). "A CIC chloride channel homolog and ornithine-containing membrane lipids of Rhizobium tropici CIAT899 are involved in symbiotic efficiency and acid tolerance". Molecular Plant-Microbe Interactions. 18(11):1175-1185. [doi:10.1094/MPMI-18-1175]16353552
2005López-Lara, IM, Gao, JL, Soto, MJ, Solares-Perez, A, Weissenmayer, B, Sohlenkamp, C, Verroios, GP, Thomas-Oates, J and Geiger, O. (2005). "Phosphorus-free membrane lipids of Sinorhizobium meliloti are not required for the symbiosis with alfalfa but contribute to increased cell yields under phosphorus-limiting conditions of growth". Molecular Plant-Microbe Interactions. 18(9):973-982. [doi:10.1094/MPMI-18-0973]16167767
2004Geiger, O, Martínez Morales, Fernando, Sohlenkamp, C and López-Lara, IM. (2004). "ROLE OF BACTERIAL PHOSPHATIDYLCHOLINE IN SYMBIOTIC AND PATHOGENIC INTERACTIONS". Biology of Molecular Plant-Microbe Interactions. ():423-426.
2004Sohlenkamp, C, de Rudder, KEE and Geiger, O. (2004). "Phosphatidylethanolamine Is Not Essential for Growth of Sinorhizobium meliloti on Complex Culture Media". Journal Of Bacteriology. 186(6):1667-1677. [doi:10.1128/JB.186.6.1667-1677.2004]14996797
2003López-Lara, IM, Sohlenkamp, C and Geiger, O. (2003). "Membrane lipids in plant-associated bacteria: Their biosyntheses and possible functions". Molecular Plant-Microbe Interactions. 16(7):567-579. [doi:10.1094/MPMI.2003.16.7.567]12848422
2003Sohlenkamp, C, López-Lara, IM and Geiger, O. (2003). "Biosynthesis of phosphatidylcholine in bacteria". Progress In Lipid Research. 42(2):115-162. [doi:10.1016/S0163-7827(02)00050-4]12547654
2002Sohlenkamp, C, Wood, CC, Roeb, GW and Udvardi, MK. (2002). "Characterization of Arabidopsis AtAMT2, a high-affinity ammonium transporter of the plasma membrane". Plant Physiology. 130(4):1788-1796. [doi:10.1104/pp.008599]12481062
2000Sohlenkamp, C, Shelden, M, Howitt, S and Udvardi, M. (2000). "Characterization of Arabidopsis AtAMT2, a novel ammonium transporter in plants". FEBS LETTERS. 467(2-3):273-278. [doi:10.1016/S0014-5793(00)01153-4]10675553
1999de Rudder, KEE, Sohlenkamp, C and Geiger, O. (1999). "Plant-exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase". JOURNAL OF BIOLOGICAL CHEMISTRY. 274(28):20011-20016. [doi:10.1074/jbc.274.28.20011]10391951
2009Laura Ramos-Vega, Ana, Davila-Martinez, Yadira, Sohlenkamp, C, Contreras-Martínez, S, Encarnación, S, Geiger, O and López-Lara, IM. (2009). "SMb20651 is another acyl carrier protein from Sinorhizobium meliloti". MICROBIOLOGY-SGM. 155(1):257-267. [doi:10.1099/mic.0.022079-0]19118366
2009Sandoval-Calderon, Mario, Geiger, O, Guan, Ziqiang, Barona-Gomez, Francisco and Sohlenkamp, C. (2009). "A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria". JOURNAL OF BIOLOGICAL CHEMISTRY. 284(26):17383-17390. [doi:10.1074/jbc.M109.006072]19439403
2004Geiger, O, Sohlenkamp, C, Martinez-Morales, F, Gao, JL, Zavaleta-Pastor, M and López-Lara, IM. (2004). "Regulation of membrane lipid biosynthesis in eubacteria". FASEB JOURNAL. 18(8, S):3-3.
2018Guerrero-Castro, Julio, Lozano, L and Sohlenkamp, C. (2018). "Dissecting the acid stress response of Rhizobium tropici CIAT 899". Frontiers in Microbiology. 9(APR):846-846. [doi:10.3389/fmicb.2018.00846]29760688
2010Zavaleta-Pastor, Maritza, Sohlenkamp, C, Gao, Jun-Lian, Guan, Ziqiang, Zaheer, Rahat, Finan, Turlough M., Raetz, Christian R. H., López-Lara, IM and Geiger, O. (2010). "Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation". PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(1):302-307. [doi:10.1073/pnas.0912930107]20018679
2013Abdel-Haliem, M.E.F., Sakr, A.A., Ali, M.F., Ghaly, M.F. and Sohlenkamp, C. (2013). "Characterization of Streptomyces isolates causing colour changes of mural paintings in ancient Egyptian tombs". Microbiological Research. 168(7):428-437. [doi:10.1016/j.micres.2013.02.004]23507492
2013Hernández Tamayo, Rogelio, Sohlenkamp, C, Puente, J.L., Brom, S and Romero, D. (2013). "Characterization of IntA, a bidirectional site-specific recombinase required for conjugative transfer of the symbiotic plasmid of Rhizobium etli CFN42". Journal Of Bacteriology. 195(20):4668-4677. [doi:10.1128/JB.00714-13]23935046
2000Sohlenkamp, C, de Rudder, KEE, Rohrs, V, López-Lara, IM and Geiger, O. (2000). "Cloning and characterization of the gene for phosphatidylcholine synthase". JOURNAL OF BIOLOGICAL CHEMISTRY. 275(25):18919-18925. [doi:10.1074/jbc.M000844200]10858449
2015Sandoval-Calderón M, Nguyen DD, Kapono CA, Herron P, Dorrestein PC and Sohlenkamp, C. (2015). "Plasticity of Streptomyces coelicolor Membrane Composition Under Different Growth Conditions and During Development". Frontiers in Microbiology. 6():1465-1465. [doi:10.3389/fmicb.2015.01465]26733994
2018Ferreira-Saab, M., Formey, D, Torres, M., Aragón, W., Padilla, E.A., Tromas, A, Sohlenkamp, C, Schwan-Estrada, K.R.F. and Serrano, M. (2018). "Compounds released by the biocontrol yeast Hanseniaspora opuntiae protect plants against Corynespora cassiicola and Botrytis Cinerea". Frontiers in Microbiology. 9(JUL):1596-1596. [doi:10.3389/fmicb.2018.01596]30065716