Previous Research

One of our main interests is to combine systems and synthetic biology using genome-scale models to design bacterial phenotypes of biotechnological interest. In addition, we are also interested in using a theoretical-experimental approach to study the genetic and metabolic mechanisms that allow bacterial populations to find collective strategies to survive in hostile and unpredictable environments, such as antimicrobial substances. On the same vein, we also seek to understand the effects of spatial structure in the temporal dynamics of the evolution of bacterial resistance to different combinations of antibiotics. Additionally, we build a variety of evolutionary models to analyze specific genomic regions, such as the sex chromosomes, which are one of the most dynamic elements in the genomes of vertebrates . Furthermore, using bacterial nitrogen fixation as an experimental model, we study the regulation of gene expression in response to various environmental stimuli and the mechanisms directing these responses (LGC).